cecropin b

Cecropin B is a small antibacterial peptide from the giant silkmoth, Hyalophora cecropia.

Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA sequences. Cecropin B acetate exhibits strong antimicrobial activity.

KN-17, a modified derivative based on the cecropin B structure, effectively disrupts bacterial growth and induces the migration of human bone marrow stromal cells (hBMSCs). This compound significantly stimulates angiogenesis both in vitro and in vivo.

Peceleganan (PL-5), a synthetic hybrid peptide, combines cecropin A (1-10) and melittin B (3-18) sequences to form a (10+16)-peptide analogue with antimicrobial properties. This compound effectively inhibits wound infections [1].

Peceleganan acetate (PL-5), a synthetic hybrid analogue combining segments of cecropin A (1-10) and melittin B (3-18) to form a (10+16)-peptide, demonstrates antimicrobial properties. It is specifically effective in inhibiting wound infections [1].