cdk8-in-4

CDK8-IN-4 (compound 16) is an effective CDK8 inhibitor (IC50=0.2 nM) for studying CDK8-related cancers.

CDK8-IN-4k is a potent and highly selective CDK8 inhibitor, with no apparent potential for time-dependent CYP3A4 inhibition.

Fipravirimat is a potent inhibitor of HIV-1 with potential applications in HIV and AIDS research.

CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.