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Results for "

cd 207

" in TargetMol Product Catalog
  • Recombinant Protein
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    TargetMol | Recombinant_Protein
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Langerin/CD207 Protein, Human, Recombinant (His)
langerin, C-type lectin domain family 4 member K, CD207 antigen, CD207
TMPJ-00526
Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae.
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer
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Langerin/CD207 Protein, Mouse, Recombinant (His)
Langerin, C-type lectin domain family 4 member K, Clec4k, Cd207, CD207
TMPH-02611
Expression system: E. coli
Length: 63-331, Extracellular Domain
Activity: Not Tested
  • Inquiry Price
20 days
Size
QTY
Buffer-exchangeable