caffeine metabolite

1,3,7-Trimethyluric acid, a purine alkaloid, occurs as a minor metabolite of caffeine in humans. It functions as an antioxidant with the ability to scavenge hydroxyl radicals and offers protective benefits against lipid peroxidation in erythrocyte membranes.

1-Methylxanthine is a caffeine derivative. 1-Methylxanthine is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.

7-Methyluric Acid is a metabolite of caffeine produced by xanthine oxidase and detectable in urine.

1,7-Dimethyluric acid is a metabolite of caffeine that serves as a biomarker for caffeine intake and can be detected in urine.

Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. In addition, Paraxanthine acts as a Na+/K+ ATPase enzymatic effector.

1,3,7-Trimethyluric Acid-D9 is intended for use as an internal standard for the quantification of 1,3,7-Trimethyluric Acid (T19792) by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.

Paraxanthine-D6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine (T4973) is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine (T4973) is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA or the adenosine A2 receptor agonist CGS 21680 in rats not habituated to caffeine. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.

Paraxanthine-D6 (Standard) is a reference standard of Paraxanthine-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Paraxanthine-d6 is used as an internal standard substance for the quantitative determination of Paraxanthine by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). Paraxanthine is an active metabolite of caffeine.

AAMU is a metabolite of Caffeine.

Methylliberine, an orally active purine alkaloid metabolite of caffeine, exhibits similar properties to its precursor.