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By Target- Apoptosis
- COX(1)
- Lipoxygenase(1)
- NF-κB(1)
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Results for "
caffeic acid phenethyl ester
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products2
Caffeic Acid Phenethyl Ester
Phenylethyl Caffeate, CAPE
T6429104594-70-9
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).
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Phenethyl ferulate
Caffeic Acid 3-Methyl Phenethyl Ester
TN233071835-85-3
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 4.35 μM and 5.75 μM, respectively.
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