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bsj 03204

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  • Inhibitors & Agonists
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    TargetMol | All_Pathways
  • PROTAC Products
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    TargetMol | PROTAC
BSJ-03-204
BSJ03204
T306002349356-09-6
BSJ-03-204 is a rationally designed PROTAC composed of cereblon and CDK ligands that functions as a potent and selective palbociclib-based CDK4/6 dual degrader, achieving nanomolar inhibition of CDK4/D1 and CDK6/D1 complexes without inducing IKZF1/3 degradation, BSJ-03-204 exhibit strong anticancer activity with improved selectivity.
  • $817
35 days
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BSJ-03-204 triTFA
T77923
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degradation of CDK4/6. It exhibits IC50 values of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1, indicating strong inhibitory capabilities. Notably, it spares IKZF1/3 from degradation and possesses anti-cancer activity [1].
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