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Results for "
brag2
" in TargetMol Product Catalog- Inhibitors & Agonists3
Bragsin2
6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one, Bragsin 2
T14775342795-08-8
Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.
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