boc-val-cit-pab-pnp

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable linker used in antibody-drug conjugate (ADC) synthesis, enabling the attachment and controlled release of therapeutics from antibodies [1].

Fmoc-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized to attach reactive groups (e.g., PNP) for drug payload conjugation. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases, enabling efficient payload release into cells.

Boc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that features a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB is useful for attaching reactive groups (e.g., PNP) to bind with drug payloads. Acidic conditions can remove the Boc protecting group, exposing the primary amine for conjugation reactions to form amides. The Val-Cit-PAB segment can be cleaved by intracellular proteases, allowing efficient payload release within cells.

Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.

Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that incorporates a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be used to attach reactive groups (such as PNP) for drug payload conjugation. The Fmoc protecting group can be removed with piperidine to expose a primary amine, facilitating amide bond formation. Val-Cit-PAB is cleaved by cellular proteases to efficiently release the payload inside cells.

Boc-PEG2-Val-Cit-PAB-OH is an enzymatically cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized for attachment to reactive groups (such as PNP) to connect with a drug payload. The Boc protecting group can be removed with acid, revealing a primary amine that serves for coupling reactions to form an amide. The Val-Cit-PAB segment is cleaved by cellular proteases, facilitating the effective release of the payload inside the cell.