bis aminooxy peg2

Bis-aminooxy-PEG2, a PEG-based linker for PROTACs, joins two essential ligands, crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a polyethylene glycol (PEG) derivative frequently used as a PEG-based linker in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a polyethylene glycol (PEG) derivative designed as a linker for PROTAC synthesis [1].

Aminooxy-PEG2-bis-PEG3-BCN is a cleavable five-unit PEG ADC linker utilized in the creation of antibody-drug conjugates (ADCs) [1]. This compound also serves as a click chemistry reagent featuring a BCN group that undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.