azide-c-2-azide

Azide-C2-Azide, a cleavable linker crucial in ADC (Antibody-Drug Conjugate) synthesis, joins cytotoxic drugs to antibodies, enabling precise delivery to target cells or proteins. Its cleavable nature ensures controlled drug release, optimizing the effectiveness of ADCs.

Ald-C2-PEG4-azide is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Azide-C2-SS-C2-biotin is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

N-Boc-N-bis(C2-PEG1-azide) is an alkyl ether-based PROTAC linker suitable for synthesizing PROTACs [1].

NH-bis(C2-PEG1-azide) is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Ald-Ph-amido-C2-PEG3-azide, a PEG-based linker for PROTACs, joins two essential ligands necessary for forming PROTAC molecules and facilitates selective protein degradation via the ubiquitin-proteasome system within cells.

AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-derived PROTAC linker suitable for the synthesis of PROTACs [1].

7-Bromoheptanoic acid is a building block.1,2It has been used in the synthesis of azide-based nicotinamide phosphoribosyltransferase (Nampt) inhibitors with anticancer activity and SAHA derivatives that inhibit histone deacetylases (HDACs). 1.Colombano, G., Travelli, C., Galli, U., et al.A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistryJ. Med. Chem.53(2)616-623(2010) 2.Suzuki, T., Nagano, Y., Kouketsu, A., et al.Novel inhibitors of human histone deacetylases: Design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamatesJ. Med. Chem.48(4)1019-1032(2005)