atomoxetine

Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selective antagonist of presynaptic norepinephrine transporters with little or no affinity for other norepinephrine receptors or other neurotransmitter transporters or receptors, but has little or no affinity for 5- hydroxytryptamine transporter. Atomoxetine selectively inhibits reuptake of norepinephrine and can be used to treat adolescents with ADHD and chronic tics.

Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.

(Rac)-Atomoxetine-D7 hydrochloride is a deuterium labeled  (Rac)-Atomoxetine hydrochloride (T68621). (Rac)-Atomoxetine hydrochloride is a racemic form of Atomoxetine hydrochloride.

Atomoxetine-D3 hydrochloride, the deuterium-labeled form of Atomoxetine hydrochloride (TMSM-3559), acts as a potent and selective noradrenalin re-uptake inhibitor with Ki values of 5, 77, and 1451 nM for the inhibition of radioligand binding to human NET, SERT, and DAT, respectively [1] [2].

Atomoxetine-D3 Hydrochloride (Standard) is a reference standard of Atomoxetine-D3 Hydrochloride intended for quantitative analysis, quality control, and related biochemical research applications. Atomoxetine-d3 hydrochloride, the deuterium-labeled form of Atomoxetine hydrochloride, acts as a potent and selective noradrenalin re-uptake inhibitor with Ki values of 5, 77, and 1451 nM for the inhibition of radioligand binding to human NET, SERT, and DAT, respectively [1] [2].

4'-hydroxy Atomoxetine glucuronide is a metabolite of the norepinephrine transporter (NET) inhibitor atomoxetine .1It is formed from atomoxetine by glucuronidation of the intermediate metabolite 4-hydroxy atomoxetine.2 1.Todor, I., Popa, A., Neag, M., et al.Evaluation of a potential metabolism-mediated drug-drug interaction between atomoxetine and bupropion in healthy volunteersJ. Pharm. Pharm. Sci.19(2)198-207(2016) 2.Sauer, J.-M., Ring, B.J., and Witcher, J.W.Clinical pharmacokinetics of atomoxetineClin. Pharmacokinet.44(6)571-590(2005)

rac Atomoxetine-D5 hydrochloride is a deuterated compound of rac Atomoxetine Hydrochloride. rac Atomoxetine Hydrochloride (T68621) has a CAS number of 82857-40-7.

Atomoxetine-d7hydrochloride (Tomoxetine-d7hydrochloride) is the deuterium-labeled version of Atomoxetine hydrochloride. This compound acts as a selective norepinephrine reuptake inhibitor, with Ki values for norepinephrine (NE), serotonin (5-HT), and dopamine (DA) transporters measured at 5 nM, 77 nM, and 1451 nM, respectively. Additionally, Atomoxetine hydrochloride serves as an effective sodium channel blocker (VGSCs) and is utilized in research concerning attention-deficit hyperactivity disorder (ADHD).

Atomoxetine hydrochloride (Standard) is a reference standard for research and analysis in studies involving Atomoxetine hydrochloride. Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.

4'-Hydroxy atomoxetine β-D-glucuronide is a reagent used in biochemical reactions.

4-Hydroxyatomoxetine-D3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine (T10145) is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine (T10145) is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.

4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.

AD109 is composed of the selective norepinephrine reuptake inhibitor Atomoxetine and the antimuscarinic agent Aroxybutynin. It demonstrates significant oral bioactivity and effectively reduces the apnea-hypopnea index (AHI).