ascochlorin

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, primarily exerts anti-tumor properties by inhibiting the STAT3 signaling pathway, inducing apoptosis, and possessing anti-inflammatory activity[1][2][3].

Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitor aimed at treating triple-negative breast cancer.

4-O-Methyl-ascochlorin (Compound MAC) is a derivative of Ascochlorin that selectively induces apoptosis and G1 phase arrest in K562 leukemia cells while downregulating c-Myc expression. It enhances the phosphorylation of AMPK and inhibits the phosphorylation of mTOR and its target proteins [including p70S6 K and 4E-BP-1]. 4-O-Methyl-ascochlorin is useful for leukemia research.