aphthous

Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.

Cetalkonium chloride(Benzylcetyldimethylammonium chloride hydrate) is an ammonium preservative with anti-inflammatory activity that can be used in the study of aphthous ulcers.

Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.

Betamethasone 17-benzoate, a representative steroid, is used in the treatment of recurrent aphthous ulcers (RAU).