aphidicolin

Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase α and δ, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].

Aphidicolin 17-acetate is a selective inhibitor of eukaryotic DNA polymerase α (DNA polymeraseα) that does not inhibit DNA polymerases β and γ. It significantly suppresses DNA synthesis in sea urchin embryos and HeLa cells in vivo without affecting RNA and protein synthesis.

Aphidicolin-3,18-orthoacetate is a derivative of Aphidicolin that inhibits the growth of rice seedling roots.

Aphidicolins B32 is a diterpene compound identified in the marine fungus Botryotinia fuckeliana. It exhibits cytotoxic activity against human bladder cancer cells by inhibiting the proliferation of T24 cells at the G0 G1 phase, with an IC50 of 27.6 μM. Aphidicolins B32 is applicable for research in the field of anticancer studies.