aphidicolin

Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase α and δ, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].

Aphidicolin 17-acetate is a selective inhibitor of eukaryotic DNA polymerase α (DNA polymeraseα) that does not inhibit DNA polymerases β and γ. It significantly suppresses DNA synthesis in sea urchin embryos and HeLa cells in vivo without affecting RNA and protein synthesis.

Aphidicolin-3,18-orthoacetate is a derivative of Aphidicolin that inhibits the growth of rice seedling roots.

3-Deoxyaphidicolin is a phytotoxin that inhibits root growth in lettuce seedlings. Additionally, 3-Deoxyaphidicolin exhibits inhibitory activity against the protozoan parasites Leishmania major and Leishmania braziliensis.

Aphidicolins B32 is a diterpene compound identified in the marine fungus Botryotinia fuckeliana. It exhibits cytotoxic activity against human bladder cancer cells by inhibiting the proliferation of T24 cells at the G0/G1 phase, with an IC50 of 27.6 μM. Aphidicolins B32 is applicable for research in the field of anticancer studies.