antischistosomal

Nilutamide (RU23908), an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors, but not for estrogen, progestogen, or glucocorticoid receptors. Therefore, Nilutamide can block the action of androgens of testicular and adrenal origin that stimulate the growth of malignant and normal prostatic tissue. Prostate Y is mainly androgen-dependent and can be treat with chemical castration or surgical. So far, antiandrogen monotherapy has not consistently been certified to be equivalent to castration.

PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.

Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM).

MC3935 (Compound 19) is an LSD1 inhibitor with an IC50 of 0.52 μM for the LSD1-CoREST enzyme complex. It shows significant antischistosomal activity against newly transformed schistosomula (NTS) and adult Schistosoma mansoni, although its onset of action is delayed against larvae. MC3935 exhibits no significant toxicity to human cells and is useful for schistosomiasis research.

LSD1-IN-44 (Compound 19) is an LSD1 inhibitor with an IC50 of 0.02 μM for the LSD1-CoREST enzyme complex. It exhibits significant antischistosomal activity against newly transformed schistosomula (NTS) and adult Schistosoma mansoni, though its effect on larvae shows some delay. LSD1-IN-44 demonstrates no notable toxicity to human cells and is applicable for schistosomiasis research.

MMV665852, an antischistosomal agent, has been shown to inhibit worm viability in vitro and reduce worm burden in S. mansoni-infected mice.

RO13-3978 is a broad-spectrum antischistosomal. Ro 13-3978 has excellent antischistosomal properties in vivo.

14,15 β-Dihydroxyklaineanone(14,15beta-Dihydroxyklaineanone) is a bittersweet compound isolated from Eurycoma longifolia with antitumor-promoting, antischistosomal and plasmodium-killing activities.