antimicrotubule

Estramustine phosphate sodium (Ro 21-8837 001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2 M phase of the cell cycle.

Taltobulin trifluoroacetate is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Taltobulin hydrochloride is a synthetic analogue of the tripeptide hemiasterlin, is a potent agent of antimicrotubule that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugates[1].

LG308 shows antimicrotubule activity which is a novel synthetic compound. LG308 induces apoptosis, cell death, and significantly suppresses tumor growth that has the potential for the prostate cancer research. LG308 induces arrest of mitotic phase and significantly inhibits progression of G2 M which is associated with the upregulation of cyclin B1 and mitotic marker MPM-2 and the dephosphorylation of cdc2 [1].

Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, effectively bypasses P-glycoprotein-mediated resistance both in vitro and in vivo as a robust antimicrotubule agent. It prevents the polymerization of purified tubulin, destabilizes cellular microtubule structures, and triggers both mitotic arrest and apoptosis [1].

DM4-d6 is a deuterated form of DM4, an antimicrotubule agent that inhibits cell division. DM4 is utilized in the preparation of antibody-drug conjugates (ADCs).

ANK peptide is a novel peptide designed based on the conserved residue of a single-anchored protein motif. It acts as an inhibitor of γ-synuclein (SNCG) by binding to SNCG, thereby competing with and disrupting the SNCG-BubR1 interaction. This action enhances the sensitivity of breast cancer cells to antimicrotubule agents such as nocodazole and paclitaxel. ANK peptide is useful for tumor research.