antiestrogenic

Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.

Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).

7-Hydroxyflavanone shows antimicrobial activity against Streptococcus pneumoniae clinical isolates.

FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally, FLTX1 demonstrates strong antiestrogenic activity in breast cancer cells, resembling the potent antiestrogenic properties of Tamoxifen. Notably, FLTX1 does not exhibit any estrogenic agonistic effect on the uterus.

22393-62-0_peak 2 exhibits some aspects of the antiestrogenic activity and other actions that may be connected to the estrogenic properties. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used in dermatology.

Endoxifen E-isomer (E-Endoxifen) is the E-isomer of (Z)-Endoxifen. Endoxifen E-isomer has antiestrogenic effects.

N-Desmethyltamoxifen, the principal metabolite of tamoxifen in humans, serves as an efficacious modulator of ceramide metabolism within human AML cells by inhibiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. Although it demonstrates weak antiestrogenic properties, it acts as a protein kinase C (PKC) inhibitor with a potency ten times greater than that of tamoxifen.

OP-1074 is a pure antiestrogen and a selective degrader of ER, demonstrating specific antiestrogenic activity for ERα and ERβ.

Zuclomiphene citrate, a cis isomer of Clomiphene citrate, exhibits an antiestrogenic effect and inhibits the secretion of luteinizing hormone (LH) more effectively than its trans isomer.

Enclomiphene-D4 is the deuterium-labeled analog of Enclomiphene. Enclomiphene (T62017) functions as a potent and orally active estrogen receptor antagonist, exhibiting antiestrogenic properties.

RU 45144 is an estradiol derivative with antiestrogenic activity.

LY 183648 has antiestrogenic activity. LY117018 inhibited PAIII metastasis to the gluteal (97%) and iliac lymph nodes (88%).

Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator (SERM) with a fixed ring structure similar to raloxifene. It exhibits potent antiestrogenic effects on breast cancer and endometrium with minimal side effects and provides beneficial estrogenic effects on bone health and lipid profile.

HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].

TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues.

Endoxifen-d5 (Z-isomer) is the deuterium-labeled form of Endoxifen (Z-isomer). Endoxifen (Z-isomer) is an orally active metabolite of Tamoxifen, which exerts antiestrogenic effects in ERα-expressing breast cancer cells. It inhibits hERG in a concentration-dependent manner, with an IC50 of 1.6 μM.

Chlorotrianisene (Standard) is a reference standard for research and analysis in studies involving Chlorotrianisene. Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.

Millewanin G shows antiestrogenic activity.

Millewanins H shows antiestrogenic activity.

Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS