antibacterial agent27

Antibacterial agent 27 has potent anti-Candida activity.

Antibacterialagent 273 (Compound 15e) is an antimicrobial agent targeting bacterial cell membranes, effectively disrupting them with a MIC value of 4 μg/mL against Staphylococcus aureus. It causes the leakage of intracellular nucleic acids and proteins, inhibits bacterial metabolic activity, and induces the accumulation of reactive oxygen species (ROS) within bacteria. Antibacterialagent 273 is applicable in research on infections caused by Staphylococcus aureus.

Antibacterialagent 272 (Compound Z22) is a potential antibacterial agent that targets the DNA and DNA-topoisomerase II (DNA-Topo II) complex. It exhibits strong antibacterial activity, with a minimum inhibitory concentration (MIC) of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853. Antibacterialagent 272 binds by intercalating between DNA base pairs, disrupting the normal function of bacterial DNA, and is suitable for research into bacterial infectious diseases.

Antibacterialagent 274 (Compound 18b) is an antibacterial agent that targets bacterial cell membranes, exhibiting a minimum inhibitory concentration (MIC) of 8 μg/mL against Acinetobacter baumannii ATCC 17978. It functions by disrupting membrane integrity, causing intracellular accumulation of ROS, which leads to DNA and protein leakage, thereby exerting its antibacterial effects. Antibacterialagent 274 is applicable in research on infections caused by Gram-negative bacteria.

Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.

Antibacterialagent 278 (compound B1) is an antimicrobial agent that exhibits potent inhibitory activity against Gram-positive bacteria.

Antibacterialagent 276 (compound B3) acts as an antimicrobial agent with EC50 values of 1.32 μg/mL against Xanthomonas oryzae pv.oryzae and 2.80 μg/mL against Xanthomonas axonopodis pv.citri. It disrupts intracellular redox balance, leading to the accumulation of reactive oxygen species and subsequently inducing apoptosis (apoptosis).

Antibacterialagent 279 (compound A12) is an effective antibacterial agent. It inhibits the SOS response of Pseudomonas aeruginosa.

Antibacterialagent 275 (Ⅲ1) is an antibacterial compound with a λmax value of 730 nm. It is applicable for research in antimicrobial photodynamic therapy (aPDT).

Antibacterialagent 270 (Compound 3e) is an antibacterial agent that targets bacterial membrane components such as phosphatidylglycerol (PG), cardiolipin (CL), and bacterial DNA. It disrupts the bacterial membrane structure and binds to DNA, interfering with genetic information transfer. Antibacterialagent 270 holds potential for research into infections caused by methicillin-resistant Staphylococcus aureus (MRSA).