antibacterial agent 31

Antibacterial agent 31 exhibits (shows) efficacy (activity) in combating (against) rice bacterial leaf streak.

Arcopilin A (compound Arcopilin A(1)) functions as an antibacterial agent with moderate inhibitory capabilities against fungal pathogens and Gram-positive bacteria, exhibiting IC 50 values of 8.9 μg/mL for KB-3-1 cells and 14 μg/mL for L929 cells. Notably, it can effectively eradicate preformed biofilms of Staphylococcus aureus. Additionally, Arcopilin A significantly boosts the efficacy of gentamicin (GM) and vancomycin (Vac), enhancing their activities by 115 and 31 times, respectively.

Antimicrobial agent-31 (compound 4a) is a potent antibacterial compound. It exhibits minimum inhibitory concentrations (MIC) of 19.24 µg/mL against Salmonella enterica serovar Typhimurium and 11.31 µg/mL against E. coli.

Anti-MRSA agent 31 (Compound 6) is an agent effective against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 97 μg/mL and a minimum bactericidal concentration (MBC) of 781.25 μg/mL. It exhibits potent antibacterial activity and significant inhibitory action on penicillin-binding protein 2a (PBP2a).