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Results for "

anti-multiple

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    79
    TargetMol | Inhibitors_Agonists
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    5
    TargetMol | Compound_Libraries
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    1
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RMC-6236
RMC6236
T746982765081-21-6
RMC-6236 is an orally effective and novel triple complex RAS (ON) MULTI inhibitor, which is a potent non covalent inhibitor of multiple RAS variants in GTP binding state. RMC-6236 has anti-tumor activity and can be used in research related to RAS driven tumors. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.
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TargetMol | Inhibitor Hot
Budesonide
Entocort, Pulmicort, Rhinocort
T009451333-22-3
Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects against multiple cells types and mediators referred to allergic and nonallergic-mediated inflammatory. What's more, the anti-inflammatory action of budesonide has been revealed to contribute to the effectiveness of asthma.
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Oltipraz
RP 35972, NSC 347901
T015364224-21-1
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.
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Dimethyl fumarate
DMF
T0492624-49-7
Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.
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4-Hydroxybenzyl alcohol
P-Methylolphenol, 4-Methylolphenol
T3752623-05-2
4-Hydroxybenzyl alcohol (P-Methylolphenol) exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K Akt pathway. 4-Hydroxybenzyl alcohol inhibit the development of new blood vessels by targeting multiple mechanisms of the angiogenic process, may as a promising candidate for the establishment of anti-angiogenic treatment strategies in cancer therapy.
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Hyperoside
Quercetin 3-galactoside, Hyperin
T2844482-36-0
Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.
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Icaritin
Cycloicaritin, Anhydroicaritin
T3398118525-40-9
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6 JAK2 STAT3 signaling. Icaritin at low concentration (4 or 8 μMol L) can promote rat chondrocyte proliferation and inhibit cell apoptosis, while the effect of Icaritin on rat chondrocyte at high concentration was reversed.
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Vicenin 2
Vicenin -2
T385123666-13-9
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants.
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TargetMol | Inhibitor Sale
CCF642
AC1LYELL
T6800346640-08-2
CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.
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SC99
T8719882290-02-0
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities
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TargetMol | Inhibitor Sale
E64FC26
T111412285446-62-8
E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer.
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6-8 weeks
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Penitrem A
T1240312627-35-9
Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
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T6167923
T130632437475-16-4
T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 μM for IFN-γ, 2.9 μM for IL-1β, and 2.66 μM each for IL-6 and TNF-α, demonstrating its efficacy across multiple inflammatory mediators [1].
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6-8 weeks
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(R)-BAY1238097
T134421564269-85-7
(R)-BAY1238097 represents the R-isomer of BAY1238097, which exhibits relatively lower activity compared to its counterpart. BAY1238097 is a highly potent and selective inhibitor targeting the binding of BET proteins to histones, demonstrating significant anti-proliferative effects in various acute myeloid leukemia (AML) and multiple myeloma (MM) models. The high activity is achieved through the down-regulation of c-Myc levels and the subsequent modulation of its downstream transcriptome.
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6-8 weeks
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Dolastatin 15
DLS 15
T15158123884-00-4
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m
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NSC745885
T163544219-52-7
NSC745885 is an effective down-regulator of EZH2 via proteasome-mediated degradation. NSC745885 is also an effective anti-tumor agent that displays selective toxicity against multiple cancer cell lines but not normal cells. NSC745885 offers possibilities
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6-8 weeks
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Hesperidin dihydrochalcone
T20001235573-79-6
Hesperidin dihydrochalcone, a non-toxic sweetener with high sweetness and low calories, exhibits multiple biological activities including anti-oxidation, liver and kidney protection, bacteriostasis, and enhancement of gastrointestinal health.
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2-4 weeks
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Ciheptolane
T20197534753-46-3
Ciheptolane, a derivative of spirodibenzocycloalkanedioxalane, exhibits multiple pharmacological activities including analgesic, sedative, antihistamine, antiserotonin, anti-inflammatory, anticonvulsant, and antidepressant effects.
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Profexalone
3-OXAZOLIDINECARBOXAMIDE, 2-OXO-5-PHENYL-N-PROPYL-
T20223434740-13-1
Profexalone is a derivative of oxazolidinone, exhibiting multiple pharmacological activities such as anticonvulsant, muscle relaxant, antidepressant, anti-inflammatory, and analgesic effects.
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AAL-149
T204642177258-60-5
AAL-149, an analog of FTY720 and a TRPM7 inhibitor (IC50 = 1.081 μM), exhibits multiple anti-inflammatory effects without targeting S1P receptors. It is applicable in anti-inflammatory research.
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10-14 weeks
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O-1663
O 1663
T24566468083-84-3
O-1663 is an advanced stage breast cancer inhibitor that acts by targeting multiple cannabinoid anti-tumor pathways.
    6-8 weeks
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    slm6
    SLM-6, SLM 6, Sangivamycin-Like Molecule 6, NSC-107517, NSC 107517
    T2880522242-91-7
    SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.
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    6-8 weeks
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    Elotuzumab
    PDL 063, HuLuc 63, Elotuzumab (anti-SLAMF7), BMS 901608
    T35386915296-00-3
    Elotuzumab(HuLuc 63) is a monoclonal antibody that targets the SLAMF7 receptor.Elotuzumab is a compound that directly activates NK cells and induces antibody-dependent cytotoxicity, and can be used in combination with lenalidomide and dexamethasone (Ld) to treat multiple myeloma.
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    Quinacrine analog 34
    T357471411646-44-0
    Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.
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    6-8 weeks
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