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(4)
By Target- Ras
- Kras(2)
- p38 MAPK(1)
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Results for "
amg 510
" in TargetMol Product Catalog- Inhibitors & Agonists4
- Isotope Products1
(S)-AMG-510
T222582252403-56-6
(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C through covalent interaction with mutant cysteine, thereby promoting clinical efficacy in KRASG12C tumors.
- $31
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QTY
Sotorasib
Cited
AMG-510
T86842296729-00-3
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.
- $31
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QTY
CitedSotorasib isomer
AMG-510 isomer
T212690
Sotorasib (AMG-510) isomer is a less active isomer of Sotorasib (AMG-510), which is a potent covalent inhibitor of KRAS G12C.
- Inquiry Price
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Sotorasib-d7
TMID-0418
Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled version of Sotorasib. Sotorasib (AMG-510) is a potent, orally bioavailable, selective covalent inhibitor of KRAS G12C. It locks KRAS G12C in the inactive GDP-bound state and causes regression of locally advanced or metastatic non-small cell lung cancer (NSCLC) with KRAS G12C mutation.
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