amentoflavone

Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2 iNOS expression.

Amentoflavone 7'',4'''-dimethyl ether is a useful organic compound for research related to life sciences and the catalog number is T125003.

2,3-Dihydroamentoflavone 7,4'-dimethyl ether exhibits cytotoxicity (ED50 values < 4 microg mL) against P-388 and HT-29 cell lines in vitro.

Tetrahydroamentoflavone is a potent XO inhibitor (IC50 = 92 nM, Ki = 982 nM) with anti-inflammatory effects. Tetrahydroamentoflavone can be used for studies about inflammation and gout.

2,3-Dihydroamentoflavone is a natural product for research related to life sciences. The catalog number is TN5490 and the CAS number is 34340-51-7.