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(2)
By Target- Antibiotic
- Apoptosis(2)
- DNA/RNA Synthesis(2)
- FXR(1)
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Detection Antibody
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Results for "
altenusin
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Natural Products3
Dehydroaltenusin
T1509431186-13-7
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity.
- $1,520
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(±)-Dehydroaltenusin
TN1156034279-44-2
(±)-Dehydroaltenusin is an antibiotic that serves as a selective inhibitor of eukaryotic DNA polymerase α (pol α), exhibiting an IC50 of 0.68 μM. It can be isolated from the fungus Alternaria tenuis. The compound competitively inhibits the activity of DNA template primers (Ki: 0.23 μM) and non-competitively inhibits the activity of 2'-deoxyribonucleoside 5'-triphosphate substrates (Ki: 0.18 μM). Additionally, (±)-Dehydroaltenusin can induce S-phase cell cycle arrest and apoptosis in cancer cells and is applicable in research on cancers such as human adenocarcinoma.
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