aloenin

1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.

1. Raspberry ketone (p-Hydroxybenzyl acetone) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can cause chemical occupational leukoderma. 2. Raspberry ketone is marketed on the Internet as a food supplement.

Aloenin B, a compound isolated from the leaves and roots of Aloe vera, has neuroprotective activity against glutamate-induced neuronal death in HT22 cells.

Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate. It impedes TNFα-stimulated NF-κB transcriptional activity, showing an IC 50 of 18.7 μM. At a concentration of 10 μM, aloenin aglycone decreases both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression in HepG2 cells exposed to 10 ng mL TNFα [1].

Aloenin-2'-p-coumaroyl ester, extracted from Aloe vera leaves, is a natural product with potential for inflammation research [1].