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akn 028

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
AKN-028
T385621175017-90-9In house
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
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AKN-028 trifluoroacetate
T298021175017-91-0
AKN-028 trifluoroacetate induces cell cycle arrest, downregulation of Myc associated genes, and dose-dependent reduction of tyrosine kinase activity in acute myeloid leukemia.
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1-2 weeks
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AKN-028 acetate
T61358
AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation and induces a dose-dependent cytotoxic response (mean IC50 = 1 μM). AKN-028 acetate also induces apoptosis by activation of caspase 3 and can be used in acute myeloid leukemia (AML) research [1].
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10-14 weeks
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