ahpc-boc

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand for von Hippel-Lindau (VHL) protein recruitment in PROTAC technology [1].

(VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH), also known as (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, is a conjugate compound comprising a ligand-linker that targets E3 ligase and features a VHL ligand on one end. It is employed in PROTAC technology applications.

(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate designed for targeting the EED protein in PROTAC applications[1].

(R,S,R)-AHPC-PEG2-C2-boc is classified as an E3 Ligase Ligand-Linker Conjugate. This compound is instrumental in the synthesis of PROTAC YAP degrader-1.

(S,R,S)-AHPC-Me-N-Boc-7-aminoheptanoic acid is a conjugate serving as an E3 ligase ligand and linker, specifically used for the synthesis of PROTACdTAGV-1 TFA.

(S,R,S)-AHPC-acetyl-azetidine-PIP-boc is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), comprising (S,R,S)-AHPC and its corresponding linker. The (S,R,S)-AHPC is a von Hippel-Lindau (VHL) ligand based on VH032 that can recruit VHL proteins. This compound serves as a crucial intermediate for synthesizing complete PROTACs molecules.

(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates). It is composed of (S,R,S)-AHPC and the corresponding linker. The (S,R,S)-AHPC component is a von Hippel-Lindau (VHL) ligand based on VH032, which can recruit the VHL protein. This compound serves as a crucial intermediate for the synthesis of complete PROTACs molecules.

(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of (S,R,S)-AHPC and the appropriate linker. The (S,R,S)-AHPC moiety is a von Hippel-Lindau (VHL) ligand based on VH032, allowing the recruitment of VHL proteins. This compound can serve as a crucial intermediate for synthesizing complete PROTACs molecules.

PROTAC YAP degrader-1, a targeted proteolysis promoting chimeric molecule, both degrades the YAP protein and inhibits its nuclear localization. This compound is formulated with Demethyl-NSC682769 as the target protein ligand, and utilizes (R,S,R)-AHPC-PEG2-C2-boc, which is the E3 ubiquitin ligase ligand + Linker conjugate. The linker incorporated in the design is Acid-PEG2-C2-Boc.

(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of (S,R,S)-AHPC and its corresponding linker. The (S,R,S)-AHPC is a von Hippel-Lindau (VHL) ligand based on VH032, capable of recruiting VHL proteins. This compound serves as a crucial intermediate in the synthesis of complete PROTAC molecules.

PROTACPTK6 ligand-O-C2-O-piperidine-Boc is a E3 Ligase Ligand-Linker Conjugates). It consists of (S,R,S)-AHPC and the corresponding linker. The (S,R,S)-AHPC is a von Hippel-Lindau (VHL) ligand based on VH032, which can recruit VHL proteins. This compound serves as a crucial intermediate for the synthesis of complete PROTACs molecules.