adc linkers

SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.

Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).

BS3 Crosslinker disodium, a non-cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs).

Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.

DOTA-NHS-ester is a linker for affibody molecules with applications in small animal PET, SPECT, and CT. It can be used to label radiotherapeutic agents or imaging probes for tumor detection.

SPDB is a degradable ADC linker that can be used to synthesize antibody-drug conjugates. SPDB is a small fragment attached to the DM4 conjugate and conjugated to the antibody using a disulfide bond.

Fmoc-Lys-OH hydrochloride is an alkyl-chain-based PROTAC linker and a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].

Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.

N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Boc-Val-Cit-OH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-Gly-Gly-OH, a cleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).

NH-bis(C1-Boc) is an uncleavable linker used for antibody-drug conjugates (ADC).

DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].

DTSSP Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

MFCD28987368 is a degradable ADC linker that can be used in the synthesis of antibody coupled drugs (ADCs).

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules.

Azido-C6-OH is a cleavable ADC linker utilized for the synthesis of antibody-drug conjugates (ADCs).