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Results for "

ac 220

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    1
    TargetMol | PROTAC
Plogosertib
CYC140
T713991137212-79-3In house
Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors.
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8-10 weeks
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Quizartinib
AC220
T2066950769-58-1
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
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TargetMol | Inhibitor Hot
HDAC3/BRD4-IN-1
T205214
HDAC3 BRD4-IN-1 (compound 26n) is an inhibitor of HDAC3 BRD4, exhibiting an IC50 of 8 nM for HDAC3, while its IC50 values for HDAC1 and HDAC2 are 220 nM and 120 nM, respectively. It displays anti-tumor and anti-proliferative effects by upregulating Ac-H3 and downregulating c-Myc. The half-life of HDAC3 BRD4-IN-1 in human liver microsomes is 29.36 minutes.
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AC-42 hydrochloride
T89072447407-36-5
AC-42 hydrochloride is the hydrochloride salt form of AC-42. It acts as a conformational agonist of the muscarinic M1 receptor (muscarinic M1 receptor), exhibiting EC50 values of 805 nM and 220 nM on human wild-type and Y381A mutant M1 receptors, respectively. Additionally, AC-42 hydrochloride stimulates the accumulation of inositol phosphates (IP) and calcium mobilization in CHO cells.
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10-14 weeks
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