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By Target- JAK
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By Target By ResearchField- Inflammation(2)
- Immune System(1)
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Results for "
abt494
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- UpadacitinibABT-494T75031310726-60-3Upadacitinib (ABT-494) is a highly potent, selective, and orally active JAK1 inhibitor with an IC₅₀ of 43 nM; its selectivity for JAK1 is approximately 74 times that for JAK2. Upadacitinib is being investigated for the treatment of autoimmune diseases such as rheumatoid arthritis and ankylosing spondylitis.
- $53
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Cited - Upadacitinib tartrateABT-494, ABT494, ABT 494T7503L1607431-21-9Upadacitinib is a potent and selective JAK inhibitor. Upadacitinib is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Upadacitinib demonstrates efficacy in rat arthritis models.
- $1,970
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