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(2)
By Target- S1P Receptor
- Hedgehog/Smoothened(1)
- Smo(1)
- Others(2)
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Results for "
abc294640
" in TargetMol Product Catalog.- Inhibitors & Agonists3
- OpaganibABC294640T6750915385-81-8Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
- $34
SizeQTY - M-25T712991186293-14-0M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.
- $1,520
SizeQTY - Opaganib HClT713011185157-59-8ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2.
- $1,520
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