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By Target- Phosphatase
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Results for "
abbv-cls 484
" in TargetMol Product Catalog- Inhibitors & Agonists2
Osunprotafib
Osunprotafib, AC484, AC 484, ABBV-CLS-484
T616992489404-97-7In house
Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. [1] Osunprotafib (ABBV-CLS-484) stimulates the tumor microenvironment and promotes natural killer cell and CD8 T cell function and enhances T cell anti-tumor immunity by enhancing JAK-STAT signaling and reducing T cell dysfunction. [2]
- $455
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QTY
PTPN2/1-IN-3
T209624
PTPN2/1-IN-3 (compound 4) is an orally active PTPN2/N1 inhibitor, developed as an improved version of ABBV-CLS-484. It demonstrates antitumor activity, with an IC50 of 9.3 nM for inhibiting PTPN2, and exhibits oral bioavailability of 93% in mice.
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