T6373

Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis.

NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.

EGFR-IN-3 is an EGFR inhibitor with potential antitumour activity.EGFR-IN-3 inhibits EGFRwt-TK and induces apoptosis (cell death), which can cause cells to block in the G2/M phase.

Carbonic anhydrase inhibitor 9 is a potent inhibitor of carbonic anhydrase (CA), targeting hCA II (Ki: 56.4 nM) and IX (Ki: 56.9 nM), and exhibits antiproliferative effects.

HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor with an IC50 of 21 pM and a Ki of 4.7 pM, demonstrating significant antiviral activity against DRV (darunavir) resistant mutants, surpassing its inhibition efficacy against wild-type viruses.

SP inhibitor 1 is an inhibitor of SARS-CoV-2 replication at non-toxic concentrations (0.3250<5.98 μM) in vitro. SP inhibitor 1 is a selective inhibitor of SARS-CoV-2 stinger protein (SP), acting on SP protein (IC50: 3.26 μM), Mpro protein (IC50>25 μM) and PLpro protein (IC50>25 μM), and has cellular antiviral effects. and PLpro protein (IC50>25 μM), and has cellular antiviral effects.

Bafrekalant is a diazabicyclo-substituted imidazo[1,2-a]pyrimidine derivative that can be used to study sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Purinephosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of Plasmodium falciparum (Pf), Plasmodium vivax (Pv), and Trypanosoma brucei (Tbr) 6-oxopurine phosphate ribosyltransferase (PRT), with Ki values of 50 nM, 20 nM, and 2 nM, respectively.

Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of Plasmodium falciparum (Pf), Plasmodium vivax (Pv), and Trypanosoma brucei (Tbr) 6-oxopurine phosphoribosyltransferase (PRT) with Ki values of 30, 20, and 2 nM, respectively.

PTP1B-IN-15 is a potent, selective protein tyrosine phosphatase 1B (PTP1B) inhibitor with research potential in type II diabetes and obesity.