T6274

RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).

DprE1-IN-1 is a potent, orally active DprE1 inhibitor that demonstrates good hepatocyte stability, low cytotoxicity, and low hERG channel inhibition. It also exhibits effective anti-branched bacilli activity in macrophages, reducing the bacterial load by 1.29 log10 CFU.

HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.

AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE with an IC50 value of 2.4 nM. It decreases amyloid aggregation in the presence of AChE, reduces tau phosphorylation of S396 residues, rescues neuronal morphology, and increases cell viability, thereby providing neuroprotection.

LpxC-IN-9 (compound 19) is a potent LpxC inhibitor with antibacterial and hypotensive activity.

AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells.

EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent inhibitor of EGFR, HER2, and CDK9, with IC50 values of 90.17 nM, 131.39 nM, and 67.04 nM, respectively, and exhibits significant anti-tumor effects.

Lorundrostat (MT-4129) is an aldosterone synthase inhibitor with antihypertensive activity that lowers systolic blood pressure.

Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer properties that can be used to study ductal adenocarcinoma of the pancreas.