T6239

Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases.

KB-5492 free base is an orally available and selective antiulcer agent that inhibits sigma receptors, inhibits [3H]1,3-di(2-tolyl)guanidine (DTG) binding to sigma receptors, and may be useful in the study of gastric lesions and gastric secretion.

KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.128-52-56-8

CSF1R-IN-8 (Compound 22) is a potent inhibitor of CSF-1R, with an IC50 of 0.012 μM.

FGFR-IN-6 (Compound 5) is an FGFR inhibitor.

PI3K-IN-34 (Compound 6g) is a highly selective inhibitor of PI3K, targeting PI3K-α (IC50: 11.73 μM), PI3K-β (IC50: 6.09 μM), and PI3K-δ (IC50: 11.18 μM), and can be used to study leukaemia.

ALK5-IN-25 (compound EX-02) is a potent ALK-5 inhibitor (IC50<10 nM) that also inhibits ALK-2 and can be used in cancer research.

ALK5-IN-31 is a selective inhibitor of ALK-5 (IC50≤10 nM) and also inhibits TGF-β-induced SMAD signalling.ALK5-IN-31 has the potential to inhibit tumour growth in vivo.ALK5-IN-31 can be used in the study of proliferative diseases (e.g. cancer, fibrotic diseases, systemic sclerosis).

ALK5-IN-32 is a selective inhibitor of ALK-5 (10 nM

OthersTGF-beta/Smad

• $1,520

8-10 weeks

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Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).

KH-3 is a potent inhibitor (IC50: 0.35 μM) of the RNA-binding protein Hu antigen R (HuR) and exhibits anti-proliferative effects. KH-3 interferes with HuR-FOXQ1 Mrna interactions, inhibits breast cancer cell invasion, and delays lung colony formation.

Apoptosis inducer 10 is a potent compound with anti-proliferative activity that induces apoptosis in HeLa (cervical cancer) cells via a mitochondria-dependent endogenous pathway.