T2163

Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin, but it has about the same pungency as capsaicin. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. The potency of dihydrocapsaicin at VR1 appears equivalent to capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic. Dihydrocapsaicin is an activator of VR1.

Myoseverin, an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and stress response genes, consistent with

LY171883 is an orally active leukotriene D4 and E4 antagonist that can be used in asthma research.

Benzyl hex-5-yn-1-ylcarbamate is a PROTAC linker used in the synthesis of PROTAC molecules.

NH2-bicyclo[1.1.1]pentane-C-OH (hydrochloride) is a PROTAC linker that is utilized in the synthesis of PROTAC molecules.

WZS0347 is a MITF PROTAC degrader. It effectively reduces MITF protein levels in several melanoma cell lines, including B16F10, A375, and GAK. WZS0347 significantly inhibits the proliferation, migration, and invasion of melanoma cells. This compound can be utilized for melanoma research.

PROTACHDAC6 degrader7 is an orally active, potent, and selective PROTAC degrader targeting histone deacetylase 6 (HDAC6) with an IC50 of 118 nM. It degrades both the catalytic domain and the zinc finger ubiquitin-binding domain of HDAC6. Furthermore, PROTACHDAC6 degrader7 inhibits the assembly and activation of the NLRP3 inflammasome and blocks the NF-κB signaling pathway, leading to reduced transcription and release of key inflammatory factors. It also decreases the mRNA levels of NLRP3, pro-IL-1β, TNF-α, and IL-6. This compound is useful for research in inflammatory bowel disease (IBD).

CRBN ligand-884 is an E3 ubiquitin ligase cereblon (CRBN) ligand designed to recruit cereblon proteins. It can be linked via a linker to a target protein ligand to form a PROTAC.

CRBN ligand-240 is an E3 ubiquitin ligase cereblon (CRBN) ligand designed to recruit cereblon proteins. It can be connected to a target protein ligand via a linker to form a PROTAC.

Thalidomide-piperidin-C-piperidin is an E3 ligase ligand-linker conjugate that comprises a CRBN-based ligand and a linker, designed for the synthesis of PROTACs.

CRBN ligand-681 is an E3 ubiquitin ligase cereblon (CRBN) ligand used for recruiting the cereblon protein. This compound can be linked via a linker to a target protein ligand to form a PROTAC.

CRBN ligand-552 is a cereblon (CRBN) ligand that functions with the E3 ubiquitin ligase to recruit cereblon proteins. It can be connected to a target protein ligand via a linker to form a PROTAC.

tert-Butyl N-({3-aminobicyclo[1.1.1]pentan-1-yl}methyl)carbamate is a PROTAC linker used in the synthesis of PROTAC molecules.

Benzyl (6-hydroxyhexyl)carbamate is a PROTAC linker used in the synthesis of PROTAC molecules.

2-Boc-2,6-Diazaspiro[3.3]heptane is a PROTAC linker, suitable for the synthesis of PROTAC molecules.

CRBN ligand-685 is a ligand of the E3 ubiquitin ligase cereblon (CRBN) and is utilized to recruit cereblon protein. It can be linked to a target protein ligand via a linker to form a PROTAC.

CRBN ligand-521 is an E3 ubiquitin ligase cereblon (CRBN) ligand designed to recruit the cereblon protein. It can be linked to a target protein ligand via a linker to form a PROTAC.

N1,N4-Dimethylbutane-1,4-diamine is a PROTAC linker used in the synthesis of PROTAC molecules.

CRBN ligand-378 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to recruit cereblon proteins. It can be conjugated to a target protein ligand via a linker to form a PROTAC.

Tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine-1-carboxylate is a PROTAC linker utilized in forming PROTAC molecules.

12-(Benzyloxy)-12-oxododecanoic acid is a PROTAC linker utilized in the synthesis of PROTAC molecules.

tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate is a PROTAC linker utilized in the synthesis of PROTAC molecules.

CRBN ligand-635 is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN) and is utilized for recruiting cereblon proteins. It can be linked to a target protein ligand via a linker to form a PROTAC.

PEG2-Dichloride (Triglycol dichloride) is a PROTAC linker used in the synthesis of PROTAC molecules.