T21482

Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, accordingly suppress gibberellin and sterol biosynthesis.

RPR-208707 is a selective inhibitor of factor Xa, exhibiting a Ki of 18 nM. It is suitable for research in thrombotic disorders.

Bosutinib N-Oxide (Compound 80) is a quinoline-based heterocyclic compound with antiproliferative activity, making it suitable for leukemia research.

AMPA receptormodulator-11 (example 210) is a positive allosteric modulator of AMPA receptors. It is useful for research in depression, schizophrenia, Alzheimer’s disease, or attention deficit hyperactivity disorder (ADHD).

SIK2/3-IN-2 (compound 12, compound I-200) is a potent SIK2/3 inhibitor, with IC50 values of 65 nM for SIK2 and 14 nM for SIK3. It also acts as an inhibitor of p21-activated kinase (PAK)1, with a Ki of 20.7 nM. SIK2/3-IN-2 is applicable in research on proliferative diseases and cancer, such as paclitaxel-resistant ovarian cancer.

MAC-0018315 is an antimicrobial agent.

Antitumor agent-148 (Example 1) is a potent anticancer compound. It effectively inhibits the growth, migration, and invasion of cancer cells. In mouse models, Antitumor agent-148 significantly suppresses the lymphatic metastasis of breast cancer cells. This agent can be used for research on various malignant tumors, including breast cancer, lung cancer, and gastric cancer.

MAO-B-IN-50 (Compound C20) is a selective MAO-B inhibitor with an IC50 value of 0.06 μM. It effectively inhibits the aggregation of Aβ40/42 and Tau proteins, with an overall IC50 of approximately 1 μM. Additionally, MAO-B-IN-50 exhibits potent and selective AChE inhibitory activity (IC50 = 1.78 μM). This compound is useful in Alzheimer's disease research.

8-(p-Sulfophenyl)theophylline (8-SPT) (compound 2) is an adenosine A2B receptor antagonist, exhibiting a Ki value of 1330 nM for human recombinant A2B receptors.

RSK4-IN-2 (compound 16o) is a potent orally active RSK4 inhibitor with an IC50 of 17 nM. It hinders the growth and invasion of esophageal squamous cell carcinoma (ESCC) cells by inhibiting the phosphorylation of RSK4 downstream targets. Additionally, RSK4-IN-2 impedes tumor growth and metastasis in a mouse model of ESCC, making it valuable for ESCC research.

Ethyl homovanillate (Compound 24) is a structural analog of eugenol. It functions as a monoamine oxidase A (MAOA) inhibitor with an IC50 value of 8.1 μM. This compound significantly improves performance in the forced swimming test in ICR mice and is applicable in the research of neurological disorders such as Alzheimer's disease.