T1835

Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.

Methyltetrazine-PEG4-oxyamine is a 4-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs), which are extensively used for targeted drug delivery [1]. This cleavable linker offers a means to efficiently attach drugs to antibodies and facilitate their controlled release at the target site.

Methyltetrazine-PEG4-SS-NHS ester is a cleavable polyethylene glycol (PEG) linker with four units, frequently used in the synthesis of antibody-drug conjugates (ADCs)[1].

Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8-unit polyethylene glycol (PEG) linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used to synthesise PROTAC molecules. Methyltetrazine-PEG5-methyltetrazine contains a Tetrazine moiety, which can be used in an iEDDA click chemistry reaction with molecules containing TCO moiety.

Methyltetrazine-PEG5-triethoxysilane is a polyethylene glycol (PEG)-based PROTAC linker suitable for PROTAC synthesis[1].

Methyltetrazine-PEG6-maleimide is a PEG-derived linker compound used for synthesizing PROTACs [1].

Methyltetrazine-PEG8-N3 is a PEG-based PROTAC linker used in the synthesis of PROTACs[1].

Methyltetrazine-PEG8-PFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs[1].

Methyltetrazine-SS-NHS, a cleavable ADC linker, is utilized for synthesizing antibody-drug conjugates (ADCs)[1].

Methyltetrazine-SS-PEG4-Biotin is a cleavable four-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Ibrutinib-D5 is a deuterium-labeled Ibrutinib. Ibrutinib (T1835) is an irreversible Btk inhibitor.