T1723

Adenosine 5'-diphosphate (ADP) is a naturally occurring nucleotide derived from the dephosphorylation of ATP. Adenosine 5'-diphosphate is essential for cellular metabolism and induces platelet aggregation.

Vicagrel is an effective, orally active antiplatelet compound that enhances the inhibitory effect of aspirin on platelet aggregation and thrombosis in rodents by irreversibly inhibiting P2Y12 receptors and reducing metabolic inactivation. Viagrel can be used to treat blood clots in coronary artery disease, peripheral vascular disease and cerebrovascular disease.

Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.

Vipivotide tetraxetan linker is formed by conjugating the pharmacophore glutamic acid-urea-lysine peptide with a linker, and is mainly used in the synthesis of vipivotide tetraxetan (PSMA-617). The glutamic acid-urea-lysine motif specifically binds to prostate-specific membrane antigen (PSMA).

VI 16832 is a broad-spectrum Type I kinase inhibitor used for comparative expression analysis of protein kinases across cancer cell lines, enabling the quantification of relative kinase abundance. VI 16832 has been employed to analyze over 170 protein kinases in multiple SILAC-encoded cancer cell lines, providing a versatile tool for kinase signaling studies and pharmacological research.

Voclosporin (ISAtx-247) is a novel, orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant used for treating lupus nephritis.

Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.

VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively).

VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).

VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 46 nM in vitro).

Adenosine 5'-diphosphate-15N5 is a 15N-labeled form of Adenosine 5'-diphosphate. This compound, known as a nucleoside diphosphate, is the dephosphorylated product of ATP by ATPases. Adenosine 5'-diphosphate (T1723) induces human platelet aggregation via action on P2T-purinergic receptors and inhibits stimulated adenylate cyclase.