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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5014 | Prostaglandin E2 | PGE2,Dinoprostone,Prostaglandin E2 (PGE2) | Endogenous Metabolite , Prostaglandin Receptor |
Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and relaxation, regulation of vasodilatation and constriction, re... | |||
T7948 | HPGDS inhibitor 2 | GSK-2894631A | PGE Synthase |
HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm. | |||
T35991 | Ent-Prostaglandin E2 | ent-Prostaglandin E2 | Others |
Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of P... | |||
T37918 | Prostaglandin E2 isopropyl ester | Prostaglandin E2 isopropyl ester | Others |
Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by end... | |||
T36045 | 1a,1b-dihomo Prostaglandin E2 | 1a,1b-dihomo Prostaglandin E2 | Others |
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also b... | |||
T36728 | 9-deoxy-9-methylene Prostaglandin E2 | 9-deoxy-9-methylene Prostaglandin E2 | Others |
9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2 . 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methyl... | |||
T36161 | 8-iso Prostaglandin E2 isopropyl ester | 8-iso Prostaglandin E2 isopropyl ester | Others |
8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid up... | |||
T37996 | 17-phenyl trinor Prostaglandin E2 ethyl amide | 17-phenyl trinor Prostaglandin E2 ethyl amide | Others |
17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rat... | |||
T2S0765 | Epibetulinic acid | NO Synthase , Prostaglandin Receptor | |
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin. | |||
T35610 | 2,5-dimethyl Celecoxib | Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor | |
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... | |||
T6S1027 | Tussilagone | Others | |
1. Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1. 2. Tussilagone has anti-cancer activity, might be a potential chemotherapeutic agent for the prevention and treatment of human co... | |||
T13488 | 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide | 2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide | Prostaglandin Receptor |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase A2 and prostaglandin E2 in rats subjected to water immersio... | |||
TN4959 | Schizandriside | Prostaglandin Receptor | |
Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells. It shows significant cyt... | |||
T68904 | GW-833972A free base | Others | |
GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus n... | |||
T36887 | 8(E),10(E),12(Z)-Octadecatrienoic Acid | Others | |
8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at c... | |||
T26925 | Butaprost | Butaprostum,TR-4979,(R)-Butaprost | Others |
Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butap... | |||
T68334 | AF3442 | Others | |
AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3... | |||
T68738 | (±)-γ-Tocopherol | Others | |
(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the syn... | |||
T83773 | Prostaglandin E2 Inhibitor 3 | PGE2 Inhibitor 3 | Others |
Prostaglandin E2 (PGE2) inhibitor 3 is a selective inhibitor targeting microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = 0.2 µM), demonstrating greater selectivity for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO... | |||
T37213 | 5-trans Latanoprost | Others | |
Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been chan... |