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Search Results for " nav1.7 "

Targets

64

Compounds

3

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12181 NaV1.7 inhibitor-1 Sodium Channel
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).
T38911 Nav1.7-IN-8 Nav1.7-IN-8
Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP...
T12184 Nav1.7 inhibitor Others
Nav1.7 inhibitor is a potent inhibitor of Nav1.7.
T12180 Nav1.7-IN-6 Others
Nav1.7-IN-6, a selective inhibitor of Nav1.7.
T28132 NaV1.7 Blocker-801
NaV1.7 Blocker-801 is a potent NaV1.7 blocker.
T12183 Nav1.7-IN-3 Others
Nav1.7-IN-3 is a selective and orally bioavailable inhibitor of voltage-gated sodium channel Nav1.7(IC50 of 8 nM).
T12182 Nav1.7-IN-2 Others
Nav1.7-IN-2 is avoltage-gated sodium channels (Nav) inhibitor in particular Nav 1.7(IC50 of 80 nM).
T8711 PF-05186462 PF-05150122 Sodium Channel
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
T7502 PF 05089771 tosylate Sodium Channel
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8...
T7336 ICA-121431 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl Sodium Channel
ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.
T12655 (Rac)-AMG8379 (Rac)-AMG8380 Sodium Channel
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.
T9685 DS-1971a Sodium Channel
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.
TQ0014 GNE-131 Sodium Channel
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).
T17263 XEN907 Others
XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM).
T7502L PF 05089771 PF-05089771,PF05089771 Sodium Channel
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.
T62000 ABBV-318
ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.
T9461 AZ194 Sodium Channel
CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.
T23439 TC-N 1752 Sodium Channel
TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.
T15174 DSP-2230 Sodium Channel
DSP-2230 is a selective blocker of Nav1.7/Nav1.8.
T9647 GX 201 GX-201 Sodium Channel
GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.
T15358 Funapide TV 45070,XEN402 Sodium Channel
Funapide (TV 45070) is a potent Sodium Channel Nav1.7 inhibitor with potential anti-inflammatory activity for the treatment of erythema gangrenosum, musculoskeletal pain, knee osteoarthritis, and postherpetic nerves.
T50030 1-(2,4-difluorophenyl)guanidine hydrochloride Others
1-(2,4-difluorophenyl)guanidine hydrochloride is a compound that is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, a key player in pain signaling. It is therefore able to reduce pain signali...
T2342 Raxatrigine CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802 Sodium Channel
Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.
T34081 Piromelatine NEU-P-11,NEU-P 11,NEU-P11 P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ...
T14201 AM-2099 Others
AM-2099 is a voltage-gated sodium channel Nav1.7 inhibitor (IC50: 0.16 μM).
T24520 NAV26 NAV-26,NAV 26
NAV26 is a selective blocker of the Nav1.7 channel.
T16487 PF-05241328 Others
PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM).
T11437 GNE-0439 Others
GNE-0439 is a novel Nav1.7-selective inhibitor (IC50: 0.34 uM) and inhibits Nav1.5 (IC50: 38.3 μM). GNE-0439 inhibits mutant N1742K channels (IC50: 0.37 uM) in membrane potential assays.
T11439 GNE-616 Others
GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype-selective Nav1.7 inhibitor (Ki: 0.79 nM, Kd: 0.38 nM for hNav1.7) for the treatment of chronic pain.
T22829 GX-674 Sodium Channel
GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of inflammatory and neuropathic pain.
T27520 GX-395 GX 395
GX-395 is a novel Nav1.7 inhibitor.
T11377 GDC-0276 Others
GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects. GDC-0276 is a potent, selective, reversible and orally active ...
T27521 GX-936 GX 936,PF 05196233,PF05196233,GX936,PF-05196233
GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.
T28371 PF-06456384 PF 6456384,PF06456384,PF6456384,PF 06456384,PF-6456384
PF-06456384 is a highly potent and selective NaV1.7 inhibitor with IC50 value of 0.01 nM.
T33943 PF-04856264 PF-4856264,PF4856264,PF 4856264
PF-04856264 is a potent and selective human Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 28 nM).
T14992 Raxatrigine hydrochloride GSK-1014802 hydrochloride,CNV1014802 (hydrochloride) Others
Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor.
T71166 PF-05150122
PF-05150122 is a novel potent and selective human Nav1.7 blocker.
T69728 SUN49199
SUN49199, also known as NaV1.7 Blocker-13, is a novel selective blocker of NaV1.7 with little affinity for NaV 1.2, 1.3, or 1.6, being more potent at human vs guinea pig NaV1.7. SUN49199 was reported in Journal of Pharm...
T16485 PF-05198007 Others
PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.
T79398 Ancistrotecine B Sodium Channel
Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].
T80042 GpTx-1 Sodium Channel
GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1].
T69915 GX-585
GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.
T80450 Pe1b μ-TrTx-Pe1b Sodium Channel
Pe1b (μ-TrTx-Pe1b) is a selective inhibitor of the NaV1.7 channel, exhibiting an inhibitory concentration 50 (IC50) value of 167 nanomolar (nM) [1].
T75856 Huwentoxin-IV TFA
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7 , Nav1.2 , Nav1.3 and Nav1.4 with IC 50 s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks per...
T80444 Phlo1b μ-TrTx-Phlo1b Sodium Channel
Phlo1b (μ-TrTx-Phlo1b), a 35-amino acid peptide toxin, selectively inhibits Nav1.7 channels with minimal inhibition of Nav1.2 and Nav1.5 [1].
TP2016 Huwentoxin-IV Huwentoxin IV
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel b...
TP1969 ProTx III
Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes ef...
T80439 GTx1-15 Sodium Channel
GTx1-15, an inhibitor cystine knot (ICK) peptide, antagonizes the voltage-dependent calcium channel Cav3.1, as well as voltage-dependent sodium channels Nav1.3 and Nav1.7 [1].
TP2070 BDS I
Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal ro...
T75250 (R)-Funapide
(R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent Nav1.7 sodium channel blocker that can be used for pain research [1] .

Compounds

NaV1.7 inhibitor-1
T12181
Synonym:
Target: Sodium Channel
Nav1.7-IN-8
T38911
Synonym: Nav1.7-IN-8
Target:
Nav1.7 inhibitor
T12184
Synonym:
Target: Others
Nav1.7-IN-6
T12180
Synonym:
Target: Others
NaV1.7 Blocker-801
T28132
Synonym:
Target:
Nav1.7-IN-3
T12183
Synonym:
Target: Others
Nav1.7-IN-2
T12182
Synonym:
Target: Others
PF-05186462
T8711
Synonym: PF-05150122
Target: Sodium Channel
PF 05089771 tosylate
T7502
Synonym:
Target: Sodium Channel
ICA-121431
T7336
Synonym: 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl
Target: Sodium Channel
(Rac)-AMG8379
T12655
Synonym: (Rac)-AMG8380
Target: Sodium Channel
DS-1971a
T9685
Synonym:
Target: Sodium Channel
GNE-131
TQ0014
Synonym:
Target: Sodium Channel
XEN907
T17263
Synonym:
Target: Others
PF 05089771
T7502L
Synonym: PF-05089771,PF05089771
Target: Sodium Channel
ABBV-318
T62000
Synonym:
Target:
AZ194
T9461
Synonym:
Target: Sodium Channel
TC-N 1752
T23439
Synonym:
Target: Sodium Channel
DSP-2230
T15174
Synonym:
Target: Sodium Channel
GX 201
T9647
Synonym: GX-201
Target: Sodium Channel
Funapide
T15358
Synonym: TV 45070,XEN402
Target: Sodium Channel
1-(2,4-difluorophenyl)guanidine hydrochloride
T50030
Synonym:
Target: Others
Raxatrigine
T2342
Synonym: CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802
Target: Sodium Channel
Piromelatine
T34081
Synonym: NEU-P-11,NEU-P 11,NEU-P11
Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel
AM-2099
T14201
Synonym:
Target: Others
NAV26
T24520
Synonym: NAV-26,NAV 26
Target:
PF-05241328
T16487
Synonym:
Target: Others
GNE-0439
T11437
Synonym:
Target: Others
GNE-616
T11439
Synonym:
Target: Others
GX-674
T22829
Synonym:
Target: Sodium Channel
GX-395
T27520
Synonym: GX 395
Target:
GDC-0276
T11377
Synonym:
Target: Others
GX-936
T27521
Synonym: GX 936,PF 05196233,PF05196233,GX936,PF-05196233
Target:
PF-06456384
T28371
Synonym: PF 6456384,PF06456384,PF6456384,PF 06456384,PF-6456384
Target:
PF-04856264
T33943
Synonym: PF-4856264,PF4856264,PF 4856264
Target:
Raxatrigine hydrochloride
T14992
Synonym: GSK-1014802 hydrochloride,CNV1014802 (hydrochloride)
Target: Others
PF-05150122
T71166
Synonym:
Target:
SUN49199
T69728
Synonym:
Target:
PF-05198007
T16485
Synonym:
Target: Others
Ancistrotecine B
T79398
Synonym:
Target: Sodium Channel
GpTx-1
T80042
Synonym:
Target: Sodium Channel
GX-585
T69915
Synonym:
Target:
Pe1b
T80450
Synonym: μ-TrTx-Pe1b
Target: Sodium Channel
Huwentoxin-IV TFA
T75856
Synonym:
Target:
Phlo1b
T80444
Synonym: μ-TrTx-Phlo1b
Target: Sodium Channel
Huwentoxin-IV
TP2016
Synonym: Huwentoxin IV
Target:
ProTx III
TP1969
Synonym:
Target:
GTx1-15
T80439
Synonym:
Target: Sodium Channel
BDS I
TP2070
Synonym:
Target:
(R)-Funapide
T75250
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T2173 Veratridine Sodium Channel
Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.
TN1254 3'-Methoxydaidzein Sodium Channel
3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla...
T82764 Cd1a β-TRTX-cd1a,β-Theraphotoxin-cd1a
Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) as well as mouse sodium ion channels (Na v 1.7). This compound...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-03275 Cytoglobin Protein, Rat, Recombinant (His & Myc) Rat E. coli
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A, Nav1.3/SCN3A, Na...
TMPH-01146 Human coronavirus HKU1 (isolate N5) Nucleoprotein/NP Protein (His & Myc) HCoV-HKU1 HEK293
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by trig...
TargetMol