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Cat No. | Product Name | Synonyms | Targets |
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T12181 | NaV1.7 inhibitor-1 | Sodium Channel | |
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7). | |||
T38911 | Nav1.7-IN-8 | Nav1.7-IN-8 | |
Nav1.7-IN-8 is a highly potent and selective inhibitor of NaV1.7, exhibiting greater selectivity for inhibiting NaV1.7 compared to the subtypes hNaV1.1 and hNaV1.5. Additionally, Nav1.7-IN-8 has inhibitory effects on CYP... | |||
T12184 | Nav1.7 inhibitor | Others | |
Nav1.7 inhibitor is a potent inhibitor of Nav1.7. | |||
T12180 | Nav1.7-IN-6 | Others | |
Nav1.7-IN-6, a selective inhibitor of Nav1.7. | |||
T28132 | NaV1.7 Blocker-801 | ||
NaV1.7 Blocker-801 is a potent NaV1.7 blocker. | |||
T12183 | Nav1.7-IN-3 | Others | |
Nav1.7-IN-3 is a selective and orally bioavailable inhibitor of voltage-gated sodium channel Nav1.7(IC50 of 8 nM). | |||
T12182 | Nav1.7-IN-2 | Others | |
Nav1.7-IN-2 is avoltage-gated sodium channels (Nav) inhibitor in particular Nav 1.7(IC50 of 80 nM). | |||
T8711 | PF-05186462 | PF-05150122 | Sodium Channel |
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5. | |||
T7502 | PF 05089771 tosylate | Sodium Channel | |
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8... | |||
T7336 | ICA-121431 | 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl | Sodium Channel |
ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels. | |||
T12655 | (Rac)-AMG8379 | (Rac)-AMG8380 | Sodium Channel |
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist. | |||
T9685 | DS-1971a | Sodium Channel | |
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. | |||
TQ0014 | GNE-131 | Sodium Channel | |
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). | |||
T17263 | XEN907 | Others | |
XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM). | |||
T7502L | PF 05089771 | PF-05089771,PF05089771 | Sodium Channel |
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent. | |||
T62000 | ABBV-318 | ||
ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders. | |||
T9461 | AZ194 | Sodium Channel | |
CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor. | |||
T23439 | TC-N 1752 | Sodium Channel | |
TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities. | |||
T15174 | DSP-2230 | Sodium Channel | |
DSP-2230 is a selective blocker of Nav1.7/Nav1.8. | |||
T9647 | GX 201 | GX-201 | Sodium Channel |
GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7. | |||
T15358 | Funapide | TV 45070,XEN402 | Sodium Channel |
Funapide (TV 45070) is a potent Sodium Channel Nav1.7 inhibitor with potential anti-inflammatory activity for the treatment of erythema gangrenosum, musculoskeletal pain, knee osteoarthritis, and postherpetic nerves. | |||
T50030 | 1-(2,4-difluorophenyl)guanidine hydrochloride | Others | |
1-(2,4-difluorophenyl)guanidine hydrochloride is a compound that is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, a key player in pain signaling. It is therefore able to reduce pain signali... | |||
T2342 | Raxatrigine | CNV1014802,CNV 1014802,GSK-1014802,CNV-1014802 | Sodium Channel |
Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression. | |||
T34081 | Piromelatine | NEU-P-11,NEU-P 11,NEU-P11 | P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel |
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... | |||
T14201 | AM-2099 | Others | |
AM-2099 is a voltage-gated sodium channel Nav1.7 inhibitor (IC50: 0.16 μM). | |||
T24520 | NAV26 | NAV-26,NAV 26 | |
NAV26 is a selective blocker of the Nav1.7 channel. | |||
T16487 | PF-05241328 | Others | |
PF-05241328 is an effective and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (IC50: 31 nM). | |||
T11437 | GNE-0439 | Others | |
GNE-0439 is a novel Nav1.7-selective inhibitor (IC50: 0.34 uM) and inhibits Nav1.5 (IC50: 38.3 μM). GNE-0439 inhibits mutant N1742K channels (IC50: 0.37 uM) in membrane potential assays. | |||
T11439 | GNE-616 | Others | |
GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype-selective Nav1.7 inhibitor (Ki: 0.79 nM, Kd: 0.38 nM for hNav1.7) for the treatment of chronic pain. | |||
T22829 | GX-674 | Sodium Channel | |
GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of inflammatory and neuropathic pain. | |||
T27520 | GX-395 | GX 395 | |
GX-395 is a novel Nav1.7 inhibitor. | |||
T11377 | GDC-0276 | Others | |
GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects. GDC-0276 is a potent, selective, reversible and orally active ... | |||
T27521 | GX-936 | GX 936,PF 05196233,PF05196233,GX936,PF-05196233 | |
GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel. | |||
T28371 | PF-06456384 | PF 6456384,PF06456384,PF6456384,PF 06456384,PF-6456384 | |
PF-06456384 is a highly potent and selective NaV1.7 inhibitor with IC50 value of 0.01 nM. | |||
T33943 | PF-04856264 | PF-4856264,PF4856264,PF 4856264 | |
PF-04856264 is a potent and selective human Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 28 nM). | |||
T14992 | Raxatrigine hydrochloride | GSK-1014802 hydrochloride,CNV1014802 (hydrochloride) | Others |
Raxatrigine hydrochloride is a state-dependent sodium channel blocker and a Nav1.7 sodium channel inhibitor. | |||
T71166 | PF-05150122 | ||
PF-05150122 is a novel potent and selective human Nav1.7 blocker. | |||
T69728 | SUN49199 | ||
SUN49199, also known as NaV1.7 Blocker-13, is a novel selective blocker of NaV1.7 with little affinity for NaV 1.2, 1.3, or 1.6, being more potent at human vs guinea pig NaV1.7. SUN49199 was reported in Journal of Pharm... | |||
T16485 | PF-05198007 | Others | |
PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor. | |||
T79398 | Ancistrotecine B | Sodium Channel | |
Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1]. | |||
T80042 | GpTx-1 | Sodium Channel | |
GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1]. | |||
T69915 | GX-585 | ||
GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2. | |||
T80450 | Pe1b | μ-TrTx-Pe1b | Sodium Channel |
Pe1b (μ-TrTx-Pe1b) is a selective inhibitor of the NaV1.7 channel, exhibiting an inhibitory concentration 50 (IC50) value of 167 nanomolar (nM) [1]. | |||
T75856 | Huwentoxin-IV TFA | ||
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7 , Nav1.2 , Nav1.3 and Nav1.4 with IC 50 s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks per... | |||
T80444 | Phlo1b | μ-TrTx-Phlo1b | Sodium Channel |
Phlo1b (μ-TrTx-Phlo1b), a 35-amino acid peptide toxin, selectively inhibits Nav1.7 channels with minimal inhibition of Nav1.2 and Nav1.5 [1]. | |||
TP2016 | Huwentoxin-IV | Huwentoxin IV | |
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel b... | |||
TP1969 | ProTx III | ||
Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes ef... | |||
T80439 | GTx1-15 | Sodium Channel | |
GTx1-15, an inhibitor cystine knot (ICK) peptide, antagonizes the voltage-dependent calcium channel Cav3.1, as well as voltage-dependent sodium channels Nav1.3 and Nav1.7 [1]. | |||
TP2070 | BDS I | ||
Potent and reversible Kv3.4 potassium channel blocker (IC50 = 47 nM); also attenuates inactivation of sodium currents by acting on Nav1.7 and Nav1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal ro... | |||
T75250 | (R)-Funapide | ||
(R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent Nav1.7 sodium channel blocker that can be used for pain research [1] . |
Cat No. | Product Name | Synonyms | Targets |
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T2173 | Veratridine | Sodium Channel | |
Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal. | |||
TN1254 | 3'-Methoxydaidzein | Sodium Channel | |
3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla... | |||
T82764 | Cd1a | β-TRTX-cd1a,β-Theraphotoxin-cd1a | |
Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) as well as mouse sodium ion channels (Na v 1.7). This compound... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03275 | Cytoglobin Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A, Nav1.3/SCN3A, Na... | |||
TMPH-01146 | Human coronavirus HKU1 (isolate N5) Nucleoprotein/NP Protein (His & Myc) | HCoV-HKU1 | HEK293 |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by trig... |