HPV

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1 2 3 6 7 11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

Larixyl acetate is a bioactive chemical.

Minnelide is a water-soluble tretinoin lactone prodrug with anticancer and antitumor activity that induces apoptosis and may prevent podocyte damage.Minnelide inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb.

Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-dependent NF-κB deinhibition. It can be used to study leukemia, head and neck squamous cell carcinoma (SCCHN).

Human Papillomavirus (HPV) E7 protein (49-57) is the H-2d-restricted HPV E749-57 epitope.

HPV16 E7 (86-93) acetate is a derived peptide of human leukocyte antigen A2.1 restricted HPV16 E7 with immunogenic property in cervical carcinomas.

HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein, demonstrating high-affinity binding to HLA-A2 in vitro.

HPV16 E7 (86-93) TFA is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide.

This is amino acids 86 to 93 fragment of the human papilloma virus (HPV) type 16 oncoprotein E7. This HPV16-encoded peptide has very high affinity of binding to the HLA-A*0201 molecule.This immunogenic fragment may be used in vaccines for the prevention a

HPV18-IN-1 (Compound H1) is a potent HPV18 inhibitor that prevents premature cell progression and abnormal proliferation in cervical cancer cells. By suppressing the E7-Rb-E2F cellular pathway and DNA methylation, HPV18-IN-1 holds potential for cancer research.

HPV16 E7 (86-93) TFA, a peptide derived from HPV16 E7, is restricted by human leukocyte antigen (HLA)-A2.1 and exhibits immunogenic properties in cervical carcinomas [1] [2].

Sabizabulin (ABI-231) is a potent, orally bioavailable α- and β-tubulin inhibitor that is active against melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells by targeting HPV E6 and E7 and is also being studied in prostate cancer.

GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , which penetrates the skin and is metabolized in the epithelium to an active nucleoside triphosphate analogue.GS-9191 has antiproliferative activity and reduces the size of papillomas in a dose-related manner.GS-9191 may be useful in the treatment of HPV-induced lesions.

Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 160 μM, respectively),with antiviral agent.

RH02007 is an inhibitor of the human papillomavirus (HPV) E6 oncoprotein.

A2ti-1 is a highly selective inhibitor of annexin A2 S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK). A2ti-1 can be used to study human papillomavirus type 16 (HPV16) infection.

A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2 S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity by selectively disrupting protein interactions between A2 and S100A10, and protects against human papillomavirus type 16 (HPV16) infection.

Lig3 is an inhibitor against high-risk strains of human papillomavirus (HPV) E6 oncoprotein.

Teslexivir hydrochloride (BTA074) is a potent antiviral agent and selective inhibitor of the E1 and E2 viral proteins' interaction, essential for DNA replication and viral production in Human Papilloma Virus (HPV) types 6 and 11. This compound is used in research on condyloma.

Astodrimer (SPL7013 free base), a large (3-4 nm, ~16.5 kDa) and negatively charged dendrimer, possesses potent virucidal capabilities. Exhibiting antiviral and virucidal activities, it effectively targets a wide array of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, and HPV. Additionally, Astodrimer demonstrates antibacterial properties [1] [2] [3].

Verpasep caltespen (HspE7), a recombinant fusion protein, originates from the Mycobacterium bovis Calmette-Guérin heat shock protein 65 (Hsp65) and is covalently bonded at its C-terminal end to the E7 protein of HPV16. This compound has applications in researching both precancerous and cancerous lesions linked to the human papillomavirus (HPV) [1] [2].

Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation by arresting the cell cycle at the S phase and induces caspase-dependent apoptosis through mitochondrial disruption. This disruption activates the ROS-mediated ubiquitin-dependent proteasome system, leading to the degradation of E6 E7 oncoproteins [1].

Human α-defensin 5 is an antiviral peptide that inhibits the infection of non-enveloped viruses such as AdV, HPV, and polyomaviruses, with an IC50 range of 0.6-1.25 μM specifically for HPV16. It functions by binding to the viral capsid and preventing viral escape from the endosome. Additionally, Human α-defensin 5 enhances HIV attachment to the cell surface and exhibits parasiticidal activity [1].

TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis