hdac4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T83947	HDAC4 CHDI Degrader 11
	HDAC4 CHDI Degrader 11 is a potent, selective degrader of HDAC4 (PROTAC) with DC_50 values of 4 nM and 6 nM in Jurkat E6-1 and Jurkat cells, respectively. This compound integrates the class IIa HDAC inhibitor trifluorome...
T1857	TMP269		HDAC
	TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.		HDAC
T6061	LMK-235	LMK235	HDAC
	LMK-235 is a potent HDAC inhibitor, and is used in cancer research.		HDAC
T3983	TMP195	TFMO 2,TMP 195	HDAC
	TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.		HDAC
T10245	ACY-957	HDAC Inhibitor C001	HDAC
	ACY-957 (HDAC Inhibitor C001) is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.		HDAC
T4481	Tucidinostat	HBI-8000,Chidamide,CS 055	HDAC
	Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and sho...		HDAC
T3199	PTACH	NCH-51,Cpd 51	HIV Protease , HDAC
	PTACH (Cpd 51) (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).		HIV Protease , HDAC
T6865	Quisinostat dihydrochloride	Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis , HDAC , Autophagy
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; g...		Apoptosis , HDAC , Autophagy
T6055	Quisinostat	JNJ-26481585	Apoptosis , HDAC , Autophagy
	Quisinostat (JNJ-26481585) (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against...		Apoptosis , HDAC , Autophagy
T6695	Tasquinimod	ABR-215050	HDAC
	Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of ac...		HDAC
T78769	HDAC6-IN-17		HDAC
	HDAC6-IN-17 (compound 5b) is a potent inhibitor of HDAC6, exhibiting IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4. It demonstrates cytotoxic activity against human cancer cell lines and is ut...		HDAC
T27235	Ebselen oxide
	Ebselen oxide is a dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9.
T68796	Thr101
	Thr101, also known as NOX Inhibitor VII, is a dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9. Thr101 is also a NOX inhibitor.
T72012	HDAC-IN-6
	HDAC-IN-6 is an HDAC inhibitor, targeting HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9.
T73031	HDAC6-IN-14
	HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1, HDAC2, HDAC3, and HDAC4.
T74783	HDAC-IN-53		HDAC
	HDAC-IN-53 is an orally active, selective inhibitor of HDAC1-3, demonstrating IC50 values of 47 nM, 125 nM, and 450 nM, respectively. It exhibits no inhibitory effects on class II HDACs (HDAC4, 5, 6, 7, 9; IC50 >10 μM). ...		HDAC
T79674	HDAC-IN-64		HDAC
	HDAC-IN-64 (Compound 13), an HDAC inhibitor, demonstrates potent inhibition of HDAC4/5/6/7/9 with IC50 values of 24, 45, 85, 31, and 37 nM, respectively. It exhibits anti-proliferative and anti-migration effects on prost...		HDAC
T73167	HDAC-IN-49
	HDAC-IN-49 is a potent, non-selective inhibitor of HDAC (HDAC), demonstrating IC50 values of 13 nM for HDAC1, 14 nM for HDAC2, 21 nM for HDAC3, 1880 nM for HDAC4, and 10 nM for HDAC6. This compound exhibits significant a...
T1890	Pracinostat	SB939	Apoptosis , HDAC
	Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and eff...		Apoptosis , HDAC
T35762	MC1742
	MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 ...
T38381	CAY17c
	CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and cla...
T14947	CHDI-390576		HDAC
	CHDI-390576 is a CNS-permeable, selective and potent dibenzoyl isohydroxamic acid class IIa histone deacetylase (HDAC) inhibitor that inhibits class IIa HDAC 4, HDAC 5, HDAC 7, HDAC 9, and can be used in cancer research.		HDAC
T16962	SW-100		HDAC
	SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the...		HDAC
T6279L	Givinostat hydrochloride	ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl	HDAC
	Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineopla...		HDAC
T78709	NT160		HDAC
	NT160, a potent class-IIa HDAC inhibitor, exhibits an IC50 of 0.046 μM and has potential applications in central nervous system disease research [1].		HDAC
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30...

Compounds

HDAC4 CHDI Degrader 11

T83947

Synonym: TFMO 2,TMP 195

Target: HDAC

ACY-957

T10245

Synonym: HDAC Inhibitor C001

Target: HDAC

Tucidinostat

T4481

Synonym: HBI-8000,Chidamide,CS 055

Target: HDAC

PTACH

T3199

Synonym: NCH-51,Cpd 51

Target: HIV Protease, HDAC

Quisinostat dihydrochloride

T6865

Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl

Target: Apoptosis, HDAC, Autophagy

Quisinostat

T6055

Synonym: JNJ-26481585

Target: Apoptosis, HDAC, Autophagy

Target: Apoptosis, HDAC

Givinostat hydrochloride

T6279L

Synonym: ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl

Cat No.	Product Name	Species	Expression System
TMPY-03431	HDAC4 Protein, Human, Recombinant (aa 612-1084)	Human	Baculovirus Insect Cells
	HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups ...

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Compounds

Recombinant Proteins

Compounds

Recombinant Proteins