Search Result

Search Results for " h /k -atpase "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T6928	Pantoprazole	SKF96022,BY1023	Apoptosis , Proton pump , Autophagy
	Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.		Apoptosis , Proton pump , Autophagy
T0161	Pantoprazole Sodium Hydrate	SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis , Potassium Channel , Proton pump , Autophagy
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.		Apoptosis , Potassium Channel , Proton pump , Autophagy
T6929	Pantoprazole sodium	Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc	Apoptosis , Others , Proton pump , HIF , Autophagy
	Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters...		Apoptosis , Others , Proton pump , HIF , Autophagy
T17030	Tegoprazan		ATPase , Proton pump
	Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5...		ATPase , Proton pump
T2404	Vonoprazan fumarate	TAK-438	ATPase
	Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase.		ATPase
T16865	SCH28080		ATPase , Proton pump
	SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an...		ATPase , Proton pump
T21254	Vonoprazan Fumarate	TAK-438,TAK 438,Vonoprazan Fumurate,TAK438	Proton pump
	Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19...		Proton pump
T10435	Linaprazan	AZD0865	Potassium Channel
	Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.		Potassium Channel
T9553	8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid		Others
	8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car is a H+/K+ ATPase inhibitor with IC50 of 0.38μM.		Others
T27812	Leminoprazole		ATPase
	Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages.		ATPase
T28136	NC-1300-B	NC 1300 B
	NC-1300-B is a proton pump. H(+)-K(+)-ATPase inhibition with NC-1300-B causes profound renal vasodilation and inhibition of renin release without affecting regulation of GFR.
T19826	Rabeprazole	LY307640	Potassium Channel , STAT
	Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers.		Potassium Channel , STAT
T1651	Rabeprazole sodium	Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium	Apoptosis , Proton pump
	Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exch...		Apoptosis , Proton pump
T20714	Levolansoprazole	(S)-Lansoprazole,(-)-Lansoprazole	Proton pump
	Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 μM). It also inhibits acid formation in isolated canine parietal cells (IC50:...		Proton pump
T1756L	Ilaprazole	IY81149,IY 81149,IY-81149	Proton pump , TOPK
	Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm...		Proton pump , TOPK
T8388	Vonoprazan	TAK-438 (free base)	Proton pump
	Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis		Proton pump
T1756	Ilaprazole sodium	IY-81149 sodium	Proton pump , TOPK
	Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus...		Proton pump , TOPK
T10221	Abeprazan hydrochloride	DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump
	Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activat...		Proton pump
T0674	Lansoprazole	A-65006,AG-1749	Proton pump , Phospholipase , Antibacterial
	Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is fo...		Proton pump , Phospholipase , Antibacterial
T2686	Esomeprazole Magnesium	(S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium	ATPase , Proton pump
	Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by block...		ATPase , Proton pump
T2686L	Esomeprazole Sodium	(S)-Omeprazole sodium	ATPase , Proton pump
	Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i...		ATPase , Proton pump
T0825	Ebselen	SPI-1005,PZ-51,CCG-39161	Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease
	Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b...
T8386	Esomeprazole Magnesium trihydrate	(S)-Omeprazole magnesium trihydrate	Proton pump
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagit...		Proton pump
T1734	Rabeprazole Sulfide	Rabeprazole Related Compound E	Proton pump , Antibacterial
	Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors.		Proton pump , Antibacterial
T2093	PF 03716556	PF-3716556	ATPase
	PF 03716556 (PF-3716556) , an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.		ATPase
T12471	Picoprazole		Others
	Picoprazole is a specific H+/K+-ATPase inhibitor (IC50 of 3.1±0.4 μM).		Others
T12822	S3337		Others
	S3337 is an inhibitor of H+, K+-ATPase		Others
T16894	SKF96067		Others
	SKF96067 is a reversible gastric H+/K+-ATPase inhibitor.		Others
T12977	Soraprazan	BYK61359	Others
	Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.		Others
T26450	A 80915A	A80915A,A-80915A
	A 80915A is A semi-naphthoquinone antibiotic from Streptomyces aculeolatus. It is a potent inhibitor of gastric (H(+)-K+)-ATPase. Inhibition by A80915A is dependent on the conformation of gastric (H(+)-K+)-ATPase, potass...
T28563	Ro 18-5364	Ro-18-5364,Ro 185364
	Ro 18-5364 is a potent inhibitor of the gastric (H+ + K+)-ATPase with an apparent Ki of 0.1 μM at pH 6.
T27092	CS-526	R-105266,R 105266,R105266
	CS-526 is a proton pump inhibitor. The inhibitory mechanism of CS-526 on H+,K+-ATPase was a competitive antagonism to the K+ binding site of H+,K+-ATPase, and it was also a reversible inhibition. CS-526 has a potent anti...
T20660	Revaprazan	SB-641257,SB 641257,SB641257
	Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs.
T23685	AHR-9294
	AHR-9294 is a novel inhibitor of H, K-ATPase. It also antagonizes gastric HCl secretion in vivo.
T30250	AZD0865	AZD-0865,AZD 0865
	AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset.
T69801	AU-461
	AU-461 is a gastric H(+)/K(+) ATPase inhibitor which acts as an anti-ulcer agent.
T28609	Rohitukine	NSC623611,NSC-623611,NSC 623611
	Rohitukine is an anti-cancer agent. It modulates apoptosis pathways through gastrin antagonism and H(+) K (+)-ATPase inhibition. Rohitukine ia an antiadipogenic, antidyslipidemic, gastroprotective, antifertility, and ant...
T76374	SPAI-1
	SPAI-1, a peptide isolated from porcine duodenum, serves as a specific inhibitor to monovalent cation transporting ATPases, effectively inhibiting Na+, K+-ATPase and H+, K+-ATPase while stimulating Mg2+-ATPase in vitro [...
T36530	Pantoprazole sulfone
	Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A4 to form pantoprazole sulfone.
T72812	(R)-Tegoprazan
	(R)-Tegoprazan, a benzimidazole derivative, serves as a potent inhibitor of kidney H+/K+-ATPase, demonstrating significant efficacy with an IC50 of 98 nM against canine kidney Na+/K+-ATPase. This compound shows promise f...
T37247	Pantoprazole Sulfide
	Pantoprazole sulfide is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4 to form pantoprazole sulfide.
T10221L	Abeprazan	DWP14012	Others
	Abeprazan (DWP14012) is a potassium-competitive acid blocker and it is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. Abeprazan inhibits H+, K+- ATPase by rev...		Others
T28156	Nepaprazole	TY-11345,TY11345,TY 11345
	Nepaprazole is a proton pump inhibitor. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes, and the inhibitory effect was enhanced under weak acid conditions, the IC50 being...
T61740	Esomeprazole hemistrontium
	Esomeprazole hemistrontium, also known as (S)-Omeprazole, is a potent and orally active proton pump inhibitor that effectively reduces acid secretion by inhibiting the H+, K+-ATPase in gastric parietal cells. This compou...
T61445	Tenatoprazole sodium
	Tenatoprazole sodium (TU-199 sodium) is a potent proton pump inhibitor that effectively suppresses the activity of hog gastric H+/K+-ATPase, a vital enzymatic pump involved in acid secretion. It achieves this inhibition ...
T62316	P-CAB agent 1
	P-CAB agent 1 (compound B19) is a potassium-competitive acid blocker that acts on H+/K+-ATPase (IC50: 60.50 nM). P-CAB agent 1 can be used in the study of acid-related diseases (ARDs).
T61467	Esomeprazole magnesium salt
	Esomeprazole magnesium salt is a potent and orally active proton pump inhibitor that effectively reduces acid secretion in gastric parietal cells by inhibiting the H+, K+-ATPase. This compound has shown promise for the r...
T61667	Esomeprazole potassium salt
	Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is an effective and orally active proton pump inhibitor that works by inhibiting the H+, K+-ATPase enzyme in the gastric parietal cells, leading to a reduction ...
T78218	Ilaprazole sodium hydrate	IY-81149 sodium hydrate	Proton pump
	Ilaprazole (IY-81149) sodium hydrate is an orally active proton pump inhibitor that irreversibly inhibits H+/K+-ATPase in rabbit parietal cells with a dose-dependent IC50 of 6 μM. It is employed in gastric ulcer research...		Proton pump
T37659	5-hydroxy Omeprazole
	5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxy...

Compounds

Pantoprazole

T6928

Synonym: SKF96022,BY1023

Target: Apoptosis, Proton pump, Autophagy

Pantoprazole Sodium Hydrate

T0161

Synonym: SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

T6929

Synonym: Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

Tegoprazan

T17030

Synonym:

Target: ATPase, Proton pump

Target: ATPase, Proton pump

Vonoprazan Fumarate

T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438

Target: Potassium Channel

8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid

Target: Potassium Channel, STAT

Rabeprazole sodium

T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Levolansoprazole

T20714

Synonym: (S)-Lansoprazole,(-)-Lansoprazole

Target: Proton pump

Ilaprazole

T1756L

Synonym: IY81149,IY 81149,IY-81149

Target: Proton pump, TOPK

Vonoprazan

T8388

Synonym: TAK-438 (free base)

Target: Proton pump

Ilaprazole sodium

T1756

Synonym: IY-81149 sodium

Target: Proton pump, TOPK

Abeprazan hydrochloride

T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Lansoprazole

T0674

Synonym: A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Esomeprazole Magnesium

T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Esomeprazole Sodium

T2686L

Synonym: (S)-Omeprazole sodium

Target: ATPase, Proton pump

Ebselen

T0825

Synonym: SPI-1005,PZ-51,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Esomeprazole Magnesium trihydrate

T8386

Synonym: (S)-Omeprazole magnesium trihydrate

Target: Proton pump

Rabeprazole Sulfide

T1734

Synonym: Rabeprazole Related Compound E

Target: Proton pump, Antibacterial

Synonym: A80915A,A-80915A

Target:

Ro 18-5364

T28563

Synonym: Ro-18-5364,Ro 185364

Target:

CS-526

T27092

Synonym: R-105266,R 105266,R105266

Target:

Revaprazan

T20660

Synonym: SB-641257,SB 641257,SB641257

Synonym: AZD-0865,AZD 0865

Synonym: NSC623611,NSC-623611,NSC 623611

Synonym: TY-11345,TY11345,TY 11345

Target:

Esomeprazole hemistrontium

Esomeprazole magnesium salt

T61467

Synonym:

Target:

Esomeprazole potassium salt

T61667

Synonym:

Target:

Ilaprazole sodium hydrate

T78218

Synonym: IY-81149 sodium hydrate

Cat No.	Product Name	Targets
TQ0184	Chebulinic acid	ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad
	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
TN4697	Odoroside H	ATPase , Potassium Channel , Sodium Channel
	Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.	ATPase , Potassium Channel , Sodium Channel
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC...

Natural Products

Chebulinic acid

TQ0184

Synonym:

Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad

Odoroside H

TN4697

Synonym:

Target: ATPase, Potassium Channel, Sodium Channel

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01892	ATP4A Protein, Human, Recombinant (His & Myc)	Human	E. coli
	The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric ...
TMPH-01893	ATP4B Protein, Human, Recombinant (GST)	Human	E. coli
	The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPH-01894	ATP4B Protein, Human, Recombinant	Human	E. coli
	The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPY-03788	ATP1B1 Protein, Human, Recombinant (His)	Human	HEK293
	ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for es...

ATP4A Protein, Human, Recombinant (His & Myc)

TMPH-01892

Species: Human

Expression System: E. coli

ATP4B Protein, Human, Recombinant (GST)

TMPH-01893

Species: Human

Expression System: E. coli

ATP4B Protein, Human, Recombinant

TMPH-01894

Species: Human

Expression System: E. coli

ATP1B1 Protein, Human, Recombinant (His)

TMPY-03788

Species: Human

Expression System: HEK293