Diastereomer

Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as an AChE inhibitor, featuring an EC50 of 45.7 μM.

Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek.

cis-Tadalafil (cis-IC-351) is a potent PDE5 inhibitor with an IC50 value of 0.09 μM that can be used to study arterial hypertension.

YN14, a mixture of diastereomers, is a PROTAC (proteolysis-targeting chimera) specifically designed for the KRASG12C protein. It acts as an efficient and selective degrader of KRASG12C, forming a stable KRASG12C:YN14:VHL ternary complex with low binding free energy (ΔG). YN14 exhibits antiproliferative properties, significantly inhibiting the growth of cancer cells with the KRASG12C mutation.

Ractopamine-D6 (Mixture of Diastereomers) is a deuterated compound of Ractopamine (Mixture of Diastereomers).

Pinaverium-D4 Bromide (Mixture of Diastereomers) is a deuterated compound of Pinaverium Bromide (Mixture of Diastereomers) (T7603). Pinaverium Bromide has a CAS number of 53251-94-8. Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.

Nadolol-D9 (Mixture of Diastereomers) is a deuterated compound of Nadolol. Nadolol has a CAS number of 42200-33-9. Nadolol is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities. Nadolol competitively blocks beta-1 adrenergic receptors located in the heart and vascular smooth muscle, inhibiting the activities of the catecholamines epinephrine and norepinephrine and producing negative inotropic and chronotropic effects. This agent exhibits antiarrhythmic activity via the impairment of atrioventricular (AV) node conduction and a corresponding reduction in sinus rate. In the kidney, inhibition of the beta-2 receptor within the juxtaglomerular apparatus results in the inhibition of renin production and a subsequent reduction in angiotensin II and aldosterone levels, thus inhibiting angiotensin II-dependent vasoconstriction and aldosterone-dependent water retention.

rac-Brivaracetam-D7 (Mixture of Diastereomers) is a deuterated compound of rac-Brivaracetam. rac-Brivaracetam has a CAS number of 357335-87-6.

Folitixorin-[D4] Disodium Salt (~80%) (Mixture Of Diastereomers) (Standard) is a reference standard of Folitixorin-[D4] Disodium Salt (~80%) (Mixture Of Diastereomers) intended for quantitative analysis, quality control, and related biochemical research applications.

Rac-Brivaracetam-[D7] (Mixture Of Diastereomers) (Standard) is a reference standard of Rac-Brivaracetam-[D7] (Mixture Of Diastereomers) intended for quantitative analysis, quality control, and related biochemical research applications.

Juvenile hormone B 3 (Juvenile hormone III bisepoxide) (mixture of diastereomers) is a sesquiterpenoid hormone. It can be isolated from the corpora allata (CA) of higher dipteran insects such as fruit flies and Drosophila melanogaster. This hormone exhibits anti-metamorphic activity and induces the expression of Kr-h1 by directly interacting with juvenile hormone (JH) receptors (Met and Gce). Juvenile hormone B 3 (mixture of diastereomers) is applicable in insect lethality studies.

1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative stress in vivo and in vitro. 3. Sa

Budesonide-D8 is a deuterated compound of Budesonide. Budesonide (T0094) has a CAS number of 51333-22-3. Budesonide, an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide (T0094) has extensively inhibitory effects against multiple cells types and mediators referred to allergic and nonallergic-mediated inflammatory. What's more, the anti-inflammatory action of budesonide has been revealed to contribute to the effectiveness of asthma.

Prasugrel Metabolite Derivative-13C-D3 is the 13C and deuterated compound of Prasugrel Metabolite Derivative.

Lurasidone Inactive Metabolite 14283-D8 is a deuterated compound of Lurasidone Inactive Metabolite 14283 (T86832). Lurasidone Inactive Metabolite 14283 has a CAS number of 186204-31-9.

Lurasidone Inactive Metabolite 14326-D8 is a deuterated compound of Lurasidone Inactive Metabolite 14326 (T11893). Lurasidone Inactive Metabolite 14326 has a CAS number of 186204-33-1.

Hydroxy carisoprodol-d4 (Hydroxy Carisoprodol [mixture of diastereomers]-d4) is the deuterium-labeled form of Hydroxy carisoprodol.

Dl-Isoleucine-D10 (Standard) is a reference standard of Dl-Isoleucine-D10 intended for quantitative analysis, quality control, and related biochemical research applications. DL-Isoleucine-d10 is a deuterated form of L-Isoleucine. L-Isoleucine is a nonpolar, hydrophobic amino acid and is classified as an essential amino acid.

Sofosbuvir impurity F (Sofosbuvir 3',5'-Bis-(S)-phosphate) is both a diastereomer of Sofosbuvir and an impurity of Sofosbuvir which is an inhibitor of HCV RNA replication.

Sofosbuvir impurity G is a diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.

(S)-AL 8810 is an 11β-fluoro analog of PGF2α, serving as a potent and selective antagonist for FP receptors. It is the C-15 diastereomer of AL 8810, with an inverted (S) configuration at C-15 compared to AL 8810, where the "natural" configuration is 15-(R).

6-epi-COTC is a diastereomer of a metabolite produced by Streptomyces, exhibiting anticancer activity.

PROTACSGK3degrader-2 is the cis-diastereomer of PROTACSGK3degrader-1 (SGK3-PROTAC1), featuring a cis-hydroxy group in its VH032 section, which prevents binding to the VHL E3 ligase. This compound inhibits SGK3, SGK1, and S6K1 with IC50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but does not degrade SGK3. It serves as a control compound for studying the specific degradation effects mediated by SGK3-PROTAC1.

(21R)-Argatroban is a diastereomer of Argatroban and acts as an inhibitor of thrombin, exhibiting anticoagulant properties. This compound is useful in research focused on coagulation inhibition.