9-aminoacridine

9-Aminoacridine is a highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.

Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).

1,8-Diazafluoren-9-one (DFO) is utilized for detecting fingerprints on porous surfaces.

Nile Red (Nile Blue A oxazone) is a strongly fluorescent stain used for the detection of intracellular lipid droplets in the presence of a hydrophobic environment.

Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.

Brilliant Blue FCF (Erioglaucine disodium salt) is a nontoxic dye for saphenous vein graft marking that abrogates response to injury.

MitoSOX Red TFA (Mito-hydroethidine TFA) is a fluorescent probe that specifically targets mitochondria in living cells.MitoSOX Red is susceptible to oxidation by superoxide, but is not easily oxidized by other ROS or RNS-generating systems.MitoSOX Red acts as a fluorescent indicator and can be used for live cell imaging.

Acid Yellow 9 monosodium salt (Hydrogen 4-aminoazobenzene-3,4'-disulphonate (sodium salt)) is an azo dye, degraded by Pseudomonas fluorescens as a sole source of nitrogen, carbon, and energy for the bacterium.

Cresyl Violet perchlorate is a red fluorescent stain employed for neuron staining.

C.I. Acid Blue 9 is an agent of dye.

TNIR7-9 is a specialized imaging probe for Tau.

BP Fluor 350 NHS ester is an amine-reactive, water-soluble dye that emits blue. It is specifically designed to efficiently modify primary amines at pH 7-9, resulting in the formation of a stable covalent amide bond.

5-FAM-NH2.HCl is a derivative fluorescent dye of 5-FAM. 5-FAM (5-Carboxyfluorescein) is a green fluorescent probe and fluorescein derivative used for labelling peptides, proteins, and nucleic acids, with excitation/emission wavelengths of 490/520 nm.

BP Fluor 594 NHS ester is a widely used tool for modifying proteins or antibodies through the labeling of primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules. The labeling process is optimal at pH 7-9, forming stable covalent amide bonds. BP Fluor 594 dye supports high molar ratio protein labeling with negligible self-quenching, resulting in brighter conjugates and more sensitive detection. BP Fluor 594 is a bright, water-soluble, pH-insensitive red fluorescent dye effective across a pH range of 4 to 10, with absorption and emission peaks at 590 and 617 nm, respectively. It is compatible with 561 nm and 594 nm laser lines. BP Fluor 594 can bind to various antibodies, peptides, proteins, tracers, and amplification substrates, and it is commonly used to generate stable signals in imaging and flow cytometry.

BP Fluor 532 NHS ester is an amine-reactive yellow fluorescent dye commonly employed for labeling proteins or antibodies through primary amines (Lys), amine-modified oligonucleotides, and other amine-containing biomolecules. The labeling process is most effective at pH 7-9, resulting in the formation of stable covalent amide bonds. BP Fluor 532 exhibits bright yellow fluorescence that is insensitive to pH changes from 4 to 10 and is optimally excited by the Nd:YAG laser line. It can bind with a variety of antibodies, peptides, proteins, tracers, and amplification substrates, and is frequently used to produce stable signals in imaging and flow cytometry.

QSY-9-succinimidyl ester is a non-fluorescent acceptor molecule featuring a terminal NHS ester group. Its quenching range is broad and intense, spanning 500-600 nm, which makes it suitable as an acceptor for fluorescence resonance energy transfer (FRET) applications with fluorescent dyes in the same wavelength range. The NHS ester can label primary amines (-NH2) on proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Serum CG probe 1 (formula (9)) is a compound used for the determination of cholylglycine in serum.

FITC-C6-LEHD-FMK is a fluorescently labeled caspase-9 inhibitor utilized for detecting active caspase-9 in apoptotic mammalian cells. This compound offers a convenient method for the sensitive detection of activated caspase-9 in live cells. Meanwhile, Z-LEHD-FMK serves as a specific caspase-9 inhibitor.

(Arg)9,TAMRA-labeled is a TAMRA-tagged cell-permeable peptide. (Arg)9 serves as a cell-penetrating peptide used for drug delivery.

8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) serves as a fluorescent probe, highly selective for hydrogen sulfide (S2−) and silicates (SiO32−). It operates by inhibiting the mechanism of intramolecular charge transfer (ICT), resulting in significant fluorescence enhancement in the presence of weak acid ions. This compound holds potential for fluorescence imaging studies of hydrogen sulfide within living cells.

PRP-194, CAS#596085-87-9, has a chemical name 5-chloro-2,3,3-trimethyl-3H-pyrrolo[2,3-b]pyridine, is a useful precursor for chemical synthesis of bioactive molecules and dyes. There is no formal name for this chemical. For the convenience of communication

7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F) is a thiol-reactive fluorogenic probe.1It has been used to quantify the levels of homocysteine, cysteine, and cysteamine in human plasma.2SBD-F displays excitation/emission maxima of 380/515 nm, respectively.1 1.Imai, K., Toyo'oka, T., and Watanabe, Y.A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonateAnal. Biochem.128(2)471-473(1983) 2.Ichinose, S., Nakamura, M., Maeda, M., et al.A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasmaBiomed. Chromatogr.23(9)935-939(2009)

Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Zimmerman, M., Ashe, B., Yurewicz, E.C., et al.Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substratesAnal. Biochem.78(1)47-51(1977) 2.Brindley, P.J., Kalinna, B.H., Dalton, J.P., et al.Proteolytic degradation of host hemoglobin by schistosomesMol. Biochem. Parasitol.89(1)1-9(1997)

L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Izquierdo, M., Lin, D., O'Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometrySLAS Discov.25(9)1064-1071(2020)