7-dehydrocholesterol

7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.

7-Dehydrocholesterol (Standard) is a reference standard for research and analysis in studies involving 7-Dehydrocholesterol. 7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.

7-Dehydrocholesterol-[13C5] (Standard) is a reference standard of 7-Dehydrocholesterol-[13C5] intended for quantitative analysis, quality control, and related biochemical research applications.

AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Δ7-Δ8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3β-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.

5-Dehydroepisterol is an antifungal sterol derivative that can be catalyzed by C-5 sterol desaturase for generation, and can be converted into 24-methylenecholesterol under the action of 7-dehydrocholesterol reductase.

Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement of membrane cholesterol with its immediate precursor 7-dehydrocholesterol, and a dramatic reduction in plasma sterol concentration. Peraclopone caused a dose-dependent decrease in cholesterol and a concomitant accumulation of provitamin D3 (7-dehydrocholesterol) in the skin, which is accompanied by an increase in the plasma level of 25-hydroxyvitamin D3. Treatment with peraclopone dramatically alters membrane sterol content in many membranes including the microvillus membrane of both the jejunum and ileum. In the jejunal microvillus membrane a major change in chemical composition occurred, presumably in response to the alteration in membrane sterol. The net result was a significant decline in both the static and dynamic component of membrane fluidity.

Boxidine inhibits the transformation of 7-dehydrocholesterol to cholesterol & also inhibits sterol absorption.

Pyrocholecalciferol, a vitamin D analogue, is produced via the photochemical transformation of 7-dehydrocholesterol (7-DHC) [1] [2].

BM 15766 sulfate, an inhibitor of 7-dehydrocholesterol δ7-reductase, effectively reduces plasma cholesterol levels and functions as a hypolipidemic agent [1] [2].