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DL-Mevalonolactone, a human endogenous metabolite, is the δ-lactone form of mevalonate, a precursor of the mevalonate pathway. It reduces mitochondrial membrane potential (∆Ψm), Ca2+ retention and NAD(P)H levels in the brain, and also induces mitochondrial swelling.DL-Mevalonolactone induces inflammation and oxidative stress, and reduces mitochondrial membrane potential.

Mevalonolactone is a sesquiterpene lactone known to inhibit calcineurin activity against p-Nitrophenyl phosphate, with an IC50 of 134.29 μM.

DL-Mevalonolactone-D7 is the deuterated form of DL-Mevalonolactone. DL-Mevalonolactone (T1353) ( (±)-Mevalonolactone; Mevalolactone) represents the δ-lactone form of mevalonic acid and serves as a precursor in the mevalonate pathway. It has the capability to reduce mitochondrial membrane potential (∆Ψm), NAD (P)H content, and the calcium ion (Ca2+) retention capacity in the brain.