666-15

666-15 is a selective CREB inhibitor with an IC50 of 81 nM. 666-15 can effectively inhibit the growth of breast cancer.

[4-(Tetrahydropyran-4-yloxy)phenyl]methylamine hydrochloride (864266-61-5 Free base) ,with CAS No. 2514927-90-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. [4-(Tetrahydropyran-4-yloxy)phenyl]methylamine hydrochloride (864266-61-5 Free base) provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

653-47 acts as a potentiator significantly enhancing the inhibitory activity of 666-15 on the cAMP-response element binding protein (CREB), while it also exhibits mild CREB inhibitory properties itself, with an IC50 value of 26.3 μM [1].

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.