6 phosphogluconic acid

6-Phosphogluconic acid is a potent and competitive inhibitor of phosphoglucose isomerase (PGI), with an apparent Ki of 0.048 mM for glucose 6-phosphate and 0.042 mM for fructose 6-phosphate as the substrate.

6-Phosphogluconic acid (tricyclohexylammonium) is a biochemical reagent used in glycobiology research. Glycobiology is the study of sugar structure, synthesis, biology, and evolution, involving carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. This field is closely connected to fundamental research, biomedicine, and biotechnology.

6-Phosphoglucono-δ-lactone (6-PGδL) serves as a reverse substrate for glucose-6-phosphate dehydrogenase (G6PDH). This compound is an intermediate in the oxidative branch of the pentose phosphate pathway (PPP). It is generated from D-glucose-6-phosphate by G6PDH and is converted to 6-phosphogluconic acid by lactonase. 6-Phosphoglucono-δ-lactone is applicable in research related to heart failure, type 2 diabetes, and cancer.