5fluorouracil

5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.

Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.

Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.

Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.

Eniluracil (GW776C85) is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitor,increases the oral bioavailability of 5-FU to 100%, facilitating uniform absorption and predictable toxicity.

1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antineoplastic agent.

Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.

5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism.

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.

5-Fluorouracil-d1 is the deuterated form of 5-Fluorouracil. 5-Fluorouracil (5-FU) is a nucleoside antimetabolite, a uracil analog with potent antitumor properties. It interferes with pyrimidine synthesis by inhibiting thymidylate synthase, depleting the intracellular dTTP pool. 5-Fluorouracil induces apoptosis and can be used as a chemosensitizer. Additionally, it inhibits the HIV virus and disrupts exosome-specific rRNA.

5-Fluorouracil-15N2 is a nitrogen-15 labeled form of 5-Fluorouracil (5-FU), a uracil analog (nucleoside antimetabolite/analog) and potent antitumor agent. It hampers pyrimidine synthesis by inhibiting thymidylate synthase, depleting the intracellular dTTP pool, inducing apoptosis, acting as a chemotherapeutic sensitizer, inhibiting HIV, and damaging exosome-specific rRNA.

5-Fluorouracil (Standard) is a reference standard for research and analysis in studies involving 5-Fluorouracil. 5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis and autophagy.

5-Fluorouracil-1-yl acetic acid methyl ester is a PNA-related Derivative.

5-Fluorouracil-1-yl acetic acid is a PNA-related Derivative.

1-(b-D-Xylofuranosyl)-5-fluorouracil is a nucleoside derivative, specifically a xylo-nucleoside and fluoro-modified nucleoside, characterized by a 5-modified pyrimidine nucleoside structure.